STNFR-1 is an early inflammatory marker in community versus institutionalized elderly women

Fernanda Matos Coelho, F. M.S. Narciso, D. M.G. Oliveira, D. S. Pereira, A. L. Teixeira, M. M. Teixeira, D. G. Souza, L. S.M. Pereira

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objective and design: To evaluate plasma sTNFR-1 and IL-6 levels and correlate with hand grip in the institutionalized and community living Brazilian elderly. Material: A convenience sample of 110 elderly women (71.17 ± 7.44 years) was selected. Plasma sTNFR-1 and IL-6 levels were measured by ELISA. For the measurement of hand grip, a JAMAR dynamometer was used. Results: Plasma concentrations of inflammatory markers were significantly higher in institutionalized elderly (sTNFR-1: 479 ± 22 pg/mL; IL-6: 6.3 ± 0.8 pg/mL) than in community-dwelling elderly (sTNFR-1: 329 ± 24 pg/mL; IL-6: 2.5 ± 0.4 pg/mL; P < 0.0001). Institutionalized elderly had reduced hand grip (15 ± 0.8 Kgf) in comparison to community dwelling elderly (23 ± 0.6 Kgf; P < 0.05). When individuals were subdivided in age groups, sTNFR-1 was higher in community dwelling versus institutionalized elderly in the 60-70 age range. Conclusions: Our results demonstrate that being institutionalized has an impact on levels of inflammatory markers.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalInflammation Research
Volume59
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Hand grip and institutionalization
  • IL-6
  • TNF

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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