Stimulus rate determines regional brain blood flow in striate cortex

Peter T. Fox, Marcus E. Raichle

Research output: Contribution to journalArticlepeer-review

213 Scopus citations


Intravenous bolus administration of oxygen 15‐labeled water and positron emission tomography were used to measure changes in brain blood flow induced by two modes of photic stimuli over a wide range of repetition rates. These stimuli (patterned‐flash and reversingd checkerboard) were chosen in order to determine whether stimulus luminacne or stimulus frequency was reponsible for previously observed increased in blood flow in the striate cortex during photic stimulation. The response curves of blood flow change as a function of stimuls rate were nearlyl suggest that elementary stimulus variables, such as repetition rate, can have a major effect on local cerebral responses, as measured with positron emission tomography and other radiotracer methods.

Original languageEnglish (US)
Pages (from-to)303-305
Number of pages3
JournalAnnals of neurology
Issue number3
StatePublished - Mar 1985
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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