Stimulatory Tests of Growth Hormone Secretion in Prepubertal Major Depression: Depressed versus Normal Children

NEAL D. RYAN, RONALD E. DAHL, BORIS BIRMAHER, DOUGLAS E. WILLIAMSON, SATISH IYENGAR, BEVERLY NELSON, JOAQUIM PUIG-ANTICH, JAMES M. PEREL

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Blunted stimulation of growth hormone (GH) secretion after pharmacological stimuli has been linked to depressive and anxiety disorders throughout the life span. This study sought to better characterize this dysregulation in prepubertal depression. GH regulation was compared in 38 medically healthy prepubertal children with current major depressive disorder and 19 control children who were medically and psychiatrically healthy. The study evaluated GH stimulatory responses to three pharmacological challenge agents: (1) insulin-induced hypoglycemia, using 0.1 IU/kg intravenous regular insulin; (2) 1.3 μg/kg intravenous clonidine; and (3) 1.0 μg/kg intravenous human growth hormone-releasing hormone (GHRH). The results provide replication and extension of earlier findings. GH responses to insulin-induced hypoglycemia and to GHRH stimulation were blunted in depressed children compared to the normal controls. Clonidine stimulation results yielded a similar picture but did not reach statistical significance. Overall these results further strengthen the evidence showing GH dysregulation in childhood depression. However, the blunted GH response seen with GHRH (which reflects pituitary hyporesponsivity) was in contrast to our original hypothesis and has implications regarding the site (or sites) of dysregulation.

Original languageEnglish (US)
Pages (from-to)824-833
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume33
Issue number6
DOIs
StatePublished - Jan 1 1994

Keywords

  • clonidine
  • depression
  • growth hormone
  • growth hormone-releasing hormone
  • insulin

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Stimulatory Tests of Growth Hormone Secretion in Prepubertal Major Depression: Depressed versus Normal Children'. Together they form a unique fingerprint.

  • Cite this

    RYAN, NEAL. D., DAHL, RONALD. E., BIRMAHER, BORIS., WILLIAMSON, DOUGLAS. E., IYENGAR, SATISH., NELSON, BEVERLY., PUIG-ANTICH, JOAQUIM., & PEREL, JAMES. M. (1994). Stimulatory Tests of Growth Hormone Secretion in Prepubertal Major Depression: Depressed versus Normal Children. Journal of the American Academy of Child and Adolescent Psychiatry, 33(6), 824-833. https://doi.org/10.1097/00004583-199407000-00008