Stimulation of rat prolactin secretion in vivo by arginine vasotocin: Influence of age of solution, nighttime administration, and dose1

Mark K. Vaughan; J. C. Little; L. Y. Johnson; G. M. Vaughan; R. J. Reiter

doi:10.1159/000122694

Stimulation of rat prolactin secretion in vivo by arginine vasotocin: Influence of age of solution, nighttime administration, and dose1

Mark K. Vaughan, J. C. Little, L. Y. Johnson, G. M. Vaughan, R. J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In male rats pretreated for 3 days with 50 μg of estradiol benzoate (E) and 25 mg of progesterone (P), the i.v. administration of 1 μg of arginine vasotocin (AVT) from solutions that were 0, 6, 24 or 48 h old caused a significant rise in plasma prolactin (Prl) 10 min after injection. In the 2nd experiment, the i.v. injection of 1 μg AVT into EP-primed adult male rats at either 01:00 (during darkness) or 13:00 h (during light) resulted in a significant and similar elevation in plasma Prl levels. In the 3rd experiment, normal adult male rats under urethane anaesthesia were given an i.v. injection of diluent or of 100 ng, 1 μg or 10 μg AVT. A significant rise in plasma Prl was observed at 10 and 20 min following injection only in the group treated with 1 μg AVT. In none of these experiments did AVT alter the content of pituitary Prl.

Original language	English (US)
Pages (from-to)	35-44
Number of pages	10
Journal	Neuroendocrinology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1159/000122694
State	Published - 1977

Keywords

Arginine vasotocin
Prolactin

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Endocrinology
Cellular and Molecular Neuroscience
Endocrinology, Diabetes and Metabolism

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10.1159/000122694

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title = "Stimulation of rat prolactin secretion in vivo by arginine vasotocin: Influence of age of solution, nighttime administration, and dose1",

abstract = "In male rats pretreated for 3 days with 50 μg of estradiol benzoate (E) and 25 mg of progesterone (P), the i.v. administration of 1 μg of arginine vasotocin (AVT) from solutions that were 0, 6, 24 or 48 h old caused a significant rise in plasma prolactin (Prl) 10 min after injection. In the 2nd experiment, the i.v. injection of 1 μg AVT into EP-primed adult male rats at either 01:00 (during darkness) or 13:00 h (during light) resulted in a significant and similar elevation in plasma Prl levels. In the 3rd experiment, normal adult male rats under urethane anaesthesia were given an i.v. injection of diluent or of 100 ng, 1 μg or 10 μg AVT. A significant rise in plasma Prl was observed at 10 and 20 min following injection only in the group treated with 1 μg AVT. In none of these experiments did AVT alter the content of pituitary Prl.",

keywords = "Arginine vasotocin, Prolactin",

author = "Vaughan, {Mark K.} and Little, {J. C.} and Johnson, {L. Y.} and Vaughan, {G. M.} and Reiter, {R. J.}",

year = "1977",

doi = "10.1159/000122694",

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journal = "Neuroendocrinology",

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T1 - Stimulation of rat prolactin secretion in vivo by arginine vasotocin

T2 - Influence of age of solution, nighttime administration, and dose1

AU - Vaughan, Mark K.

AU - Little, J. C.

AU - Johnson, L. Y.

AU - Vaughan, G. M.

AU - Reiter, R. J.

PY - 1977

Y1 - 1977

N2 - In male rats pretreated for 3 days with 50 μg of estradiol benzoate (E) and 25 mg of progesterone (P), the i.v. administration of 1 μg of arginine vasotocin (AVT) from solutions that were 0, 6, 24 or 48 h old caused a significant rise in plasma prolactin (Prl) 10 min after injection. In the 2nd experiment, the i.v. injection of 1 μg AVT into EP-primed adult male rats at either 01:00 (during darkness) or 13:00 h (during light) resulted in a significant and similar elevation in plasma Prl levels. In the 3rd experiment, normal adult male rats under urethane anaesthesia were given an i.v. injection of diluent or of 100 ng, 1 μg or 10 μg AVT. A significant rise in plasma Prl was observed at 10 and 20 min following injection only in the group treated with 1 μg AVT. In none of these experiments did AVT alter the content of pituitary Prl.

AB - In male rats pretreated for 3 days with 50 μg of estradiol benzoate (E) and 25 mg of progesterone (P), the i.v. administration of 1 μg of arginine vasotocin (AVT) from solutions that were 0, 6, 24 or 48 h old caused a significant rise in plasma prolactin (Prl) 10 min after injection. In the 2nd experiment, the i.v. injection of 1 μg AVT into EP-primed adult male rats at either 01:00 (during darkness) or 13:00 h (during light) resulted in a significant and similar elevation in plasma Prl levels. In the 3rd experiment, normal adult male rats under urethane anaesthesia were given an i.v. injection of diluent or of 100 ng, 1 μg or 10 μg AVT. A significant rise in plasma Prl was observed at 10 and 20 min following injection only in the group treated with 1 μg AVT. In none of these experiments did AVT alter the content of pituitary Prl.

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Stimulation of rat prolactin secretion in vivo by arginine vasotocin: Influence of age of solution, nighttime administration, and dose1

Abstract

Keywords

ASJC Scopus subject areas

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