Stimulation of rat prolactin secretion in vivo by arginine vasotocin: Influence of age of solution, nighttime administration, and dose1

Mark K. Vaughan, J. C. Little, L. Y. Johnson, G. M. Vaughan, R. J. Reiter

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In male rats pretreated for 3 days with 50 μg of estradiol benzoate (E) and 25 mg of progesterone (P), the i.v. administration of 1 μg of arginine vasotocin (AVT) from solutions that were 0, 6, 24 or 48 h old caused a significant rise in plasma prolactin (Prl) 10 min after injection. In the 2nd experiment, the i.v. injection of 1 μg AVT into EP-primed adult male rats at either 01:00 (during darkness) or 13:00 h (during light) resulted in a significant and similar elevation in plasma Prl levels. In the 3rd experiment, normal adult male rats under urethane anaesthesia were given an i.v. injection of diluent or of 100 ng, 1 μg or 10 μg AVT. A significant rise in plasma Prl was observed at 10 and 20 min following injection only in the group treated with 1 μg AVT. In none of these experiments did AVT alter the content of pituitary Prl.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalNeuroendocrinology
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1977

Keywords

  • Arginine vasotocin
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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