Stimulation of Growth of a Transplantable Hepatoma in Rats by Parenteral Nutrition

Ivan L. Cameron; William A. Pavlat

doi:10.1093/jnci/56.3.597

Stimulation of Growth of a Transplantable Hepatoma in Rats by Parenteral Nutrition

Ivan L. Cameron, William A. Pavlat

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Abstract

Young BUF rats of similar ages were inoculated with the transplantable Morris hepatoma #7777. At 4 weeks after inoculation, 1 group was given total iv (parenteral) feeding at high caloric and nutritional levels for 2 weeks. Such total iv feeding (hyperalimentation) of rats stimulated a more rapid tumor growth in the host. In addition, the tumors from rats fed parenterally for 2 weeks had higher mitotic activity and larger areas of necrosis, which indicate that iv feeding caused the tumor to undergo faster cell turnover with greater cell production and cell loss. Analysis of organ weights showed that parenteral feeding caused atrophy of the intestines, whereas spleen weights of the hepatoma-bearing rats fed iv were greater than those of the orally fed hepatoma-bearing rats.—J Natl Cancer Inst 56: 597-602, 1976.

Original language	English (US)
Pages (from-to)	597-602
Number of pages	6
Journal	Journal of the National Cancer Institute
Volume	56
Issue number	3
DOIs	https://doi.org/10.1093/jnci/56.3.597
State	Published - Mar 1976
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Stimulation of Growth of a Transplantable Hepatoma in Rats by Parenteral Nutrition",

abstract = "Young BUF rats of similar ages were inoculated with the transplantable Morris hepatoma #7777. At 4 weeks after inoculation, 1 group was given total iv (parenteral) feeding at high caloric and nutritional levels for 2 weeks. Such total iv feeding (hyperalimentation) of rats stimulated a more rapid tumor growth in the host. In addition, the tumors from rats fed parenterally for 2 weeks had higher mitotic activity and larger areas of necrosis, which indicate that iv feeding caused the tumor to undergo faster cell turnover with greater cell production and cell loss. Analysis of organ weights showed that parenteral feeding caused atrophy of the intestines, whereas spleen weights of the hepatoma-bearing rats fed iv were greater than those of the orally fed hepatoma-bearing rats.—J Natl Cancer Inst 56: 597-602, 1976.",

author = "Cameron, {Ivan L.} and Pavlat, {William A.}",

note = "Funding Information: 1 Received July 17, 1975; accepted September 23, 1975. 2 Supported by the Morrison Trust and by Public Health Service research grant CA16831·01 from the National Cancer Institute. .s Department of Anatomy, The UniverSity of Texas Health Sci· ence Center at San Antonio, 7703. Floyd Curl Drive, San Antonio, Texas 78284.",

year = "1976",

month = mar,

doi = "10.1093/jnci/56.3.597",

language = "English (US)",

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journal = "Journal of the National Cancer Institute",

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T1 - Stimulation of Growth of a Transplantable Hepatoma in Rats by Parenteral Nutrition

AU - Cameron, Ivan L.

AU - Pavlat, William A.

N1 - Funding Information: 1 Received July 17, 1975; accepted September 23, 1975. 2 Supported by the Morrison Trust and by Public Health Service research grant CA16831·01 from the National Cancer Institute. .s Department of Anatomy, The UniverSity of Texas Health Sci· ence Center at San Antonio, 7703. Floyd Curl Drive, San Antonio, Texas 78284.

PY - 1976/3

Y1 - 1976/3

N2 - Young BUF rats of similar ages were inoculated with the transplantable Morris hepatoma #7777. At 4 weeks after inoculation, 1 group was given total iv (parenteral) feeding at high caloric and nutritional levels for 2 weeks. Such total iv feeding (hyperalimentation) of rats stimulated a more rapid tumor growth in the host. In addition, the tumors from rats fed parenterally for 2 weeks had higher mitotic activity and larger areas of necrosis, which indicate that iv feeding caused the tumor to undergo faster cell turnover with greater cell production and cell loss. Analysis of organ weights showed that parenteral feeding caused atrophy of the intestines, whereas spleen weights of the hepatoma-bearing rats fed iv were greater than those of the orally fed hepatoma-bearing rats.—J Natl Cancer Inst 56: 597-602, 1976.

AB - Young BUF rats of similar ages were inoculated with the transplantable Morris hepatoma #7777. At 4 weeks after inoculation, 1 group was given total iv (parenteral) feeding at high caloric and nutritional levels for 2 weeks. Such total iv feeding (hyperalimentation) of rats stimulated a more rapid tumor growth in the host. In addition, the tumors from rats fed parenterally for 2 weeks had higher mitotic activity and larger areas of necrosis, which indicate that iv feeding caused the tumor to undergo faster cell turnover with greater cell production and cell loss. Analysis of organ weights showed that parenteral feeding caused atrophy of the intestines, whereas spleen weights of the hepatoma-bearing rats fed iv were greater than those of the orally fed hepatoma-bearing rats.—J Natl Cancer Inst 56: 597-602, 1976.

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Stimulation of Growth of a Transplantable Hepatoma in Rats by Parenteral Nutrition

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