Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha

K. J. Ibbotson, D. R. Twardzik, S. M. D'Souza, W. R. Hargreaves, G. J. Todaro, G. R. Mundy

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-α) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-α prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.

Original languageEnglish (US)
Pages (from-to)1007-1009
Number of pages3
JournalScience
Volume228
Issue number4702
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • General

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