Kinins, antidiuretic hormone, and several of their analogues stimulated contractile rat kidney mesangial cells growing in culture to produce prostaglandins E2, F2α, and I2. Analogues that are known to be pharmacologically active stimulated arachidonic acid metabolism in these cells, whereas compounds that have little activity were ineffective. Stimulation of arachidonic acid metabolism by these agonists appeared to be receptor-mediated. It is possible that arachidonic acid metabolism is stimulated by contraction of mesangial cells and the released prostaglandins regulate glomerular function.
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