Stimulation of arachidonic acid metabolism in rat kidney mesangial cells by bradykinin, antidiuretic hormone, and their analogues

Adriana Uglesity, Jeffrey I. Kreisberg, Lawrence Levine

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Kinins, antidiuretic hormone, and several of their analogues stimulated contractile rat kidney mesangial cells growing in culture to produce prostaglandins E2, F, and I2. Analogues that are known to be pharmacologically active stimulated arachidonic acid metabolism in these cells, whereas compounds that have little activity were ineffective. Stimulation of arachidonic acid metabolism by these agonists appeared to be receptor-mediated. It is possible that arachidonic acid metabolism is stimulated by contraction of mesangial cells and the released prostaglandins regulate glomerular function.

Original languageEnglish (US)
Pages (from-to)83-93
Number of pages11
JournalProstaglandins, Leukotrienes and Medicine
Issue number1
StatePublished - Jan 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology

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