Abstract
Modulation of MgSO4 for SO2 derivative - induced stimulation on voltage - gated sodium channels in rat hippocampal neurons was investigated by using the whole-cell patch clamp techniques. The results indicated that MgSO4 attenuated SO2 derivative-induced augment on Na+ currents, and this action was positively related with the concentration of MgSO4 but negatively related with the concentration of SO2 derivatives. In addition, adding MgSO 4 at different times would obviously inhibit the effect of SO 2 derivatives on Na+ currents. It suggested that MgSO 4 inhibited SO2 derivative-induced stimulation on voltage-gated sodium channels in rat hippocampal neurons, which implicates the possible mechanisms for MgSO4 protecting neuron against neuronal dysfunction resulting from SO2 exposure.
Original language | English (US) |
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Pages (from-to) | 74-77 |
Number of pages | 4 |
Journal | Chinese Journal of Applied and Environmental Biology |
Volume | 14 |
Issue number | 1 |
State | Published - Feb 25 2008 |
Externally published | Yes |
Keywords
- Hippocampal neurons
- MgSO
- SO derivative
- Voltage-gated sodium channel
- Whole-cell patch-clamp technique
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Pollution
- Genetics
- Agronomy and Crop Science