Stimulation effect of SO2 derivatives modulated by MgSO 4 on sodium channels in rat hippocampal neurons

Nan Sang, Yang Yun, Guangke Li, Ziqiang Meng, Chu Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Modulation of MgSO4 for SO2 derivative - induced stimulation on voltage - gated sodium channels in rat hippocampal neurons was investigated by using the whole-cell patch clamp techniques. The results indicated that MgSO4 attenuated SO2 derivative-induced augment on Na+ currents, and this action was positively related with the concentration of MgSO4 but negatively related with the concentration of SO2 derivatives. In addition, adding MgSO 4 at different times would obviously inhibit the effect of SO 2 derivatives on Na+ currents. It suggested that MgSO 4 inhibited SO2 derivative-induced stimulation on voltage-gated sodium channels in rat hippocampal neurons, which implicates the possible mechanisms for MgSO4 protecting neuron against neuronal dysfunction resulting from SO2 exposure.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalChinese Journal of Applied and Environmental Biology
Volume14
Issue number1
StatePublished - Feb 25 2008
Externally publishedYes

Keywords

  • Hippocampal neurons
  • MgSO
  • SO derivative
  • Voltage-gated sodium channel
  • Whole-cell patch-clamp technique

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pollution
  • Genetics
  • Agronomy and Crop Science

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