STIM proteins

Dynamic calcium signal transducers

Jonathan Soboloff, Brad S. Rothberg, Madesh Muniswamy, Donald L. Gill

Research output: Contribution to journalReview article

368 Citations (Scopus)

Abstract

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca2+ stored within the ER lumen. As ER Ca2+ is released to generate primary Ca2+ signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca2+-selective Orai channels to mediate finely controlled Ca 2+ signals and to homeostatically balance cellular Ca2+. Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.

Original languageEnglish (US)
Pages (from-to)549-565
Number of pages17
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

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Transducers
Endoplasmic Reticulum
Calcium
Proteins
Cell Membrane
Stromal Interaction Molecules
Membranes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

STIM proteins : Dynamic calcium signal transducers. / Soboloff, Jonathan; Rothberg, Brad S.; Muniswamy, Madesh; Gill, Donald L.

In: Nature Reviews Molecular Cell Biology, Vol. 13, No. 9, 01.09.2012, p. 549-565.

Research output: Contribution to journalReview article

Soboloff, Jonathan ; Rothberg, Brad S. ; Muniswamy, Madesh ; Gill, Donald L. / STIM proteins : Dynamic calcium signal transducers. In: Nature Reviews Molecular Cell Biology. 2012 ; Vol. 13, No. 9. pp. 549-565.
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