Stem Cells for Improving the Treatment of Neurodevelopmental Disorders

Jennifer J. Donegan, Daniel J. Lodge

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Treatment options for neurodevelopmental disorders such as schizophrenia and autism are currently limited. Antipsychotics used to treat schizophrenia are not effective for all patients, do not target all symptoms of the disease, and have serious adverse side effects. There are currently no FDA-approved drugs to treat the core symptoms of autism. In an effort to develop new and more effective treatment strategies, stem cell technologies have been used to reprogram adult somatic cells into induced pluripotent stem cells, which can be differentiated into neuronal cells and even three-dimensional brain organoids. This new technology has the potential to elucidate the complex mechanisms that underlie neurodevelopmental disorders, offer more relevant platforms for drug discovery and personalized medicine, and may even be used to treat the disease.

Original languageEnglish (US)
Pages (from-to)1118-1130
Number of pages13
JournalStem Cells and Development
Issue number17
StatePublished - Sep 1 2020


  • IPSC
  • autism
  • neurons
  • organoids
  • schizophrenia

ASJC Scopus subject areas

  • Hematology
  • Developmental Biology
  • Cell Biology


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