Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

Paul R. Crisostomo, Meijing Wang, Troy A. Markel, Tim Lahm, Aaron M. Abarbanell, Jeremy L. Herrmann, Daniel R. Meldrum

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
Issue number4
StatePublished - Oct 2007
Externally publishedYes


  • Cardioprotection
  • HGF
  • MSC
  • Mesenchymal
  • Signaling
  • VEGF

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine


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