Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease

Tricia A. Van Laar, Camaron Hole, S. L. Rajasekhar Karna, Christine L. Miller, Robert Reddick, Floyd L. Wormley, J. Seshu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall biogenesis. Statins have been shown to inhibit B. burgdorferi in vitro. Using a mouse model of Lyme disease, we found that statins contribute to reducing bacterial burden and altering the murine immune response to favor clearance of spirochetes.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalMicrobes and Infection
Volume18
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Borrelia burgdorferi
  • Cell wall biogenesis
  • Lyme disease
  • Statins

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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