Statin use moderates APOE's and CRP's associations with dementia and is associated with lesser dementia severity in ε4 carriers

Donald R. Royall, Raymond F. Palmer

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: We tested the effect of statins on C-reactive protein (CRP) and apolipoprotein E (APOE)'s associations with dementia severity. METHODS: A total of 1725 participants of the Alzheimer's Disease Neuroimaging Initiative (ADNI) were assigned from 12-month follow-up data into the following groups: (1) ε4 (–)/statin (–), (2) ε4 (–)/statin (+), (3) ε4 (+)/statin (–), and (4) ε4 (+)/statin (+). Dementia severity was assessed by a δ homolog: “dHABS.” A mediation model was stratified on statin use and moderation effects tested by a chi-square difference. RESULTS: Plasma CRP level decreased with ε4 allelic dose. Statins had no effect on the dHABS d-score in non-carriers but were associated with better scores in carriers. Treated carriers did not have more severe dementia than non-carriers. Statin use moderated the mutual adjusted effects of APOE and CRP. CRP was not a mediator of APOE's effect. DISCUSSION: Statins may provide a protective effect on the dementia severity of ε4 carriers. Highlights: δ is a dementia-specific phenotype related to general intelligence “g” and is assessed via a “d-score.” Apolipoprotein E (APOE) and plasma C-reactive protein (CRP) are independently associated with δ. Plasma CRP decreases with ε4 allelic dose. Statins were associated with better (less demented) d-scores in ε4 carriers but had no effect in non-ε4 carriers. Treated ε4 carriers did not have more severe dementia than non-carriers. Statin use moderated the effects of APOE and CRP on δ. CRP was not a mediator of APOE's effect on δ.

Original languageEnglish (US)
Pages (from-to)1627-1636
Number of pages10
JournalAlzheimer's and Dementia
Volume20
Issue number3
DOIs
StatePublished - Mar 2024

Keywords

  • aging
  • biomarkers
  • cognition
  • dementia
  • g
  • intelligence
  • statins

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology

Fingerprint

Dive into the research topics of 'Statin use moderates APOE's and CRP's associations with dementia and is associated with lesser dementia severity in ε4 carriers'. Together they form a unique fingerprint.

Cite this