Standardized mean regional method for calculating global positron emission tomographic measurements

J. S. Perlmutter, P. Herscovitch, W. J. Powers, P. T. Fox, M. E. Raichle

Research output: Contribution to journalArticle

17 Scopus citations


A new 'mean regional' method for calculating global hemispheric values of blood flow, blood volume, and metabolism with positron emission tomography is presented. It is based on a standardized set of regions defined according to coordinates in a stereotactic atlas of the brain. Region locations in each individual scan were determined by a localization technique that is independent of the appearance of the physiological images. Measurements obtained with this mean regional method minimize contributions from nonbrain structures such as ventricles or venous sinuses and provide the necessary basis for comparisons among different subjects and laboratories.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number3
Publication statusPublished - Jan 1 1985


ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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