Standardization of an experimental murine model of invasive pulmonary aspergillosis

Donald C. Sheppard; John R. Graybill; Laura K. Najvar; Lisa Y. Chiang; Thomas Doedt; William R. Kirkpatrick; Rosie Bocanegra; Ana C. Vallor; Thomas F. Patterson; Scott G. Filler

doi:10.1128/AAC.00787-06

Standardization of an experimental murine model of invasive pulmonary aspergillosis

Donald C. Sheppard
, John R. Graybill
, Laura K. Najvar
, Lisa Y. Chiang
, Thomas Doedt
, William R. Kirkpatrick
, Rosie Bocanegra
, Ana C. Vallor
, Thomas F. Patterson
, Scott G. Filler

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

Original language	English (US)
Pages (from-to)	3501-3503
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00787-06
State	Published - Oct 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Standardization of an experimental murine model of invasive pulmonary aspergillosis",

abstract = "Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.",

author = "Sheppard, \{Donald C.\} and Graybill, \{John R.\} and Najvar, \{Laura K.\} and Chiang, \{Lisa Y.\} and Thomas Doedt and Kirkpatrick, \{William R.\} and Rosie Bocanegra and Vallor, \{Ana C.\} and Patterson, \{Thomas F.\} and Filler, \{Scott G.\}",

year = "2006",

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language = "English (US)",

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AU - Sheppard, Donald C.

AU - Graybill, John R.

AU - Najvar, Laura K.

AU - Chiang, Lisa Y.

AU - Doedt, Thomas

AU - Kirkpatrick, William R.

AU - Bocanegra, Rosie

AU - Vallor, Ana C.

AU - Patterson, Thomas F.

AU - Filler, Scott G.

PY - 2006/10

Y1 - 2006/10

N2 - Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

AB - Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

UR - https://www.scopus.com/pages/publications/33749505685

UR - https://www.scopus.com/pages/publications/33749505685#tab=citedBy

U2 - 10.1128/AAC.00787-06

DO - 10.1128/AAC.00787-06

M3 - Article

C2 - 17005844

AN - SCOPUS:33749505685

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EP - 3503

JO - Antimicrobial agents and chemotherapy

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IS - 10

ER -

Standardization of an experimental murine model of invasive pulmonary aspergillosis

Abstract

ASJC Scopus subject areas

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