Standardization of an experimental murine model of invasive pulmonary aspergillosis

Donald C. Sheppard; John R. Graybill; Laura K. Najvar; Lisa Y. Chiang; Thomas Doedt; William R. Kirkpatrick; Rosie Bocanegra; Ana C. Vallor; Thomas F. Patterson; Scott G. Filler

doi:10.1128/AAC.00787-06

Standardization of an experimental murine model of invasive pulmonary aspergillosis

Donald C. Sheppard, John R. Graybill, Laura K. Najvar, Lisa Y. Chiang, Thomas Doedt, William R. Kirkpatrick, Rosie Bocanegra, Ana C. Vallor, Thomas F. Patterson, Scott G. Filler

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

Original language	English (US)
Pages (from-to)	3501-3503
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00787-06
State	Published - Oct 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Standardization of an experimental murine model of invasive pulmonary aspergillosis",

abstract = "Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.",

author = "Sheppard, \{Donald C.\} and Graybill, \{John R.\} and Najvar, \{Laura K.\} and Chiang, \{Lisa Y.\} and Thomas Doedt and Kirkpatrick, \{William R.\} and Rosie Bocanegra and Vallor, \{Ana C.\} and Patterson, \{Thomas F.\} and Filler, \{Scott G.\}",

year = "2006",

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language = "English (US)",

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AU - Sheppard, Donald C.

AU - Graybill, John R.

AU - Najvar, Laura K.

AU - Chiang, Lisa Y.

AU - Doedt, Thomas

AU - Kirkpatrick, William R.

AU - Bocanegra, Rosie

AU - Vallor, Ana C.

AU - Patterson, Thomas F.

AU - Filler, Scott G.

PY - 2006/10

Y1 - 2006/10

N2 - Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

AB - Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

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U2 - 10.1128/AAC.00787-06

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AN - SCOPUS:33749505685

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JF - Antimicrobial agents and chemotherapy

IS - 10

ER -

Standardization of an experimental murine model of invasive pulmonary aspergillosis

Abstract

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