Standardization of an experimental murine model of invasive pulmonary aspergillosis

Donald C. Sheppard, John R. Graybill, Laura K. Najvar, Lisa Y. Chiang, Thomas Doedt, William R. Kirkpatrick, Rosie Bocanegra, Ana C. Vallor, Thomas F. Patterson, Scott G. Filler

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

Original languageEnglish (US)
Pages (from-to)3501-3503
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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