Standardization of an experimental murine model of invasive pulmonary aspergillosis

Donald C. Sheppard, John R. Graybill, Laura K. Najvar, Lisa Y. Chiang, Thomas Doedt, William R. Kirkpatrick, Rosie Bocanegra, Ana C. Vallor, Thomas F Patterson, Scott G. Filler

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

Original languageEnglish (US)
Pages (from-to)3501-3503
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number10
DOIs
StatePublished - Oct 2006

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Invasive Pulmonary Aspergillosis
Theoretical Models
Aspergillosis
Aerosols
Animal Models
Infection
Therapeutics
liposomal amphotericin B

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Sheppard, D. C., Graybill, J. R., Najvar, L. K., Chiang, L. Y., Doedt, T., Kirkpatrick, W. R., ... Filler, S. G. (2006). Standardization of an experimental murine model of invasive pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 50(10), 3501-3503. https://doi.org/10.1128/AAC.00787-06

Standardization of an experimental murine model of invasive pulmonary aspergillosis. / Sheppard, Donald C.; Graybill, John R.; Najvar, Laura K.; Chiang, Lisa Y.; Doedt, Thomas; Kirkpatrick, William R.; Bocanegra, Rosie; Vallor, Ana C.; Patterson, Thomas F; Filler, Scott G.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 10, 10.2006, p. 3501-3503.

Research output: Contribution to journalArticle

Sheppard, DC, Graybill, JR, Najvar, LK, Chiang, LY, Doedt, T, Kirkpatrick, WR, Bocanegra, R, Vallor, AC, Patterson, TF & Filler, SG 2006, 'Standardization of an experimental murine model of invasive pulmonary aspergillosis', Antimicrobial Agents and Chemotherapy, vol. 50, no. 10, pp. 3501-3503. https://doi.org/10.1128/AAC.00787-06
Sheppard DC, Graybill JR, Najvar LK, Chiang LY, Doedt T, Kirkpatrick WR et al. Standardization of an experimental murine model of invasive pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy. 2006 Oct;50(10):3501-3503. https://doi.org/10.1128/AAC.00787-06
Sheppard, Donald C. ; Graybill, John R. ; Najvar, Laura K. ; Chiang, Lisa Y. ; Doedt, Thomas ; Kirkpatrick, William R. ; Bocanegra, Rosie ; Vallor, Ana C. ; Patterson, Thomas F ; Filler, Scott G. / Standardization of an experimental murine model of invasive pulmonary aspergillosis. In: Antimicrobial Agents and Chemotherapy. 2006 ; Vol. 50, No. 10. pp. 3501-3503.
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