TY - JOUR
T1 - SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice
AU - Richardson, Jennelle Durnett
AU - Aanonsen, Lin
AU - Hargreaves, Kenneth M.
N1 - Funding Information:
This work was supported by a predoctoral fellowship from the Howard Hughes Medical Institute and by NIH DE9860.
PY - 1997/1/29
Y1 - 1997/1/29
N2 - Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4- methyl-3-pyrazolecarboxamide) on mouse hot plate latencies. Intrathecal injection of SR 141716A evoked a significant thermal hyperalgesia. These results suggest that the cannabinoid system tonically regulates thermal nociceptive thresholds. Furthermore, the absence of this regulation results in hyperalgesia suggesting that hypoactivity of this system may be involved in certain types of chronic pain.
AB - Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4- methyl-3-pyrazolecarboxamide) on mouse hot plate latencies. Intrathecal injection of SR 141716A evoked a significant thermal hyperalgesia. These results suggest that the cannabinoid system tonically regulates thermal nociceptive thresholds. Furthermore, the absence of this regulation results in hyperalgesia suggesting that hypoactivity of this system may be involved in certain types of chronic pain.
KW - Cannabinoid
KW - Hyperalgesia
KW - Pain
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U2 - 10.1016/S0014-2999(96)00952-1
DO - 10.1016/S0014-2999(96)00952-1
M3 - Article
C2 - 9042616
AN - SCOPUS:0031032872
SN - 0014-2999
VL - 319
SP - R3-R4
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -