SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice

Jennelle Durnett Richardson, Lin Aanonsen, Kenneth M. Hargreaves

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4- methyl-3-pyrazolecarboxamide) on mouse hot plate latencies. Intrathecal injection of SR 141716A evoked a significant thermal hyperalgesia. These results suggest that the cannabinoid system tonically regulates thermal nociceptive thresholds. Furthermore, the absence of this regulation results in hyperalgesia suggesting that hypoactivity of this system may be involved in certain types of chronic pain.

Original languageEnglish (US)
Pages (from-to)R3-R4
JournalEuropean Journal of Pharmacology
Volume319
Issue number2-3
DOIs
StatePublished - Jan 29 1997
Externally publishedYes

Keywords

  • Cannabinoid
  • Hyperalgesia
  • Pain

ASJC Scopus subject areas

  • Pharmacology

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