Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation

Erich J. Sohn; David S. Libich

doi:10.1016/j.str.2024.06.007

Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS^1-267 and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS^1–267 molecules that have adopted β-strand conformations.

Original language	English (US)
Pages (from-to)	854-855
Number of pages	2
Journal	Structure
Volume	32
Issue number	7
DOIs	https://doi.org/10.1016/j.str.2024.06.007
State	Published - Jul 11 2024

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2024.06.007

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title = "Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation",

abstract = "In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS1-267 and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS1–267 molecules that have adopted β-strand conformations.",

author = "Sohn, {Erich J.} and Libich, {David S.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

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AU - Libich, David S.

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N2 - In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS1-267 and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS1–267 molecules that have adopted β-strand conformations.

AB - In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS1-267 and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS1–267 molecules that have adopted β-strand conformations.

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Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation

Abstract

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