Spontaneous ovarian tumors in twelve baboons: A review of ovarian neoplasms in non-human primates

Charleen M. Moore, Gene B. Hubbard, M. Michelle Leland, Betty G. Dunn, Robert G. Best

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Twelve spontaneous ovarian tumors were found in the Southwest Foundation for Biomedical Research baboon colony. These included four granulosa cell tumors, three teratomas, two endometrioid carcinomas, one seromucinous cystadenofibroma, a cystic papillary adenocarcinoma, and an ovarian carcinoma. Age was a pre-disposing factor. With one exception, the tumors of surface epithelial- and sex cordstromal origin occurred in baboons over 17 years of age. The exceptional animal was 7 years of age when a malignant granulosa cell tumor with Sertoli cell differentiation was identified. The two endometrioid tumors, which were found in 17- and 30-year-old animals, were both associated with endometriosis. In contrast, the teratomas, which are tumors of germ cell origin, were found in younger animals, i.e. 17 years of age or younger. One case of an ovarian carcinoma with metastases was observed in a 6-month-old infant. Cases of spontaneous ovarian tumors from the literature are reviewed.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalJournal of medical primatology
Issue number1
StatePublished - Feb 2003
Externally publishedYes


  • Adenocarcinoma
  • Age
  • Endometrioid carcinoma
  • Granulosa cell tumor
  • Malignancy
  • Model
  • Ovarian carcinoma
  • Teratoma

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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