TY - JOUR
T1 - Spontaneous hyphema associated with ingestion of aspirin and ethanol
AU - Kageler, W. V.
AU - Moake, J. L.
AU - Garcia, C. A.
N1 - Funding Information:
A 42-year-old healthy white woman developed pain in her left eye four hours after consuming 10 to 15 oz of ethanol. The pain was associated with photophobia, lacrimation, and decreased visual acuity. The patient denied orbital, periorbital, or head trauma. There was no history qf previous ocular defect or excessive bleeding during abdominal surgical procedures (appendectomy and cholecystectomy). She had been taking three to five aspirin tablets (300 mg) weekly for various mi]d, nonspecific complaints, and intermittently consumed several ounces of ethanol. She had recently noted "easy bruising." The blood pressure was 120/76 and the general physical examination showed a few small ecchymotic lesions on the extremities. There was bilateral conjunctival hyperemia with subconjunctival hemorrhages and a 70% hyphema in the left eye (Fig. 1). There were no ecchymotic lesions or other indications of injury to the head, neck, or periorbital areas. The left eye had light perception only, with an From the Division of Hematology, Department of Medicine (Drs. Kageler and Moake), and the Department of Ophthalmology (Dr. Garcia), University of Texas Medical School, Houston, Texas. This study was supported in part by Public Health Service grant 1-S01-RR05745-01. Reprint requests to J. L. Moake, M.D., Director, Division of Hematology, University of Texas Medical School, 6400 W. Cullen St., Houston, TX 77025.
PY - 1976/10
Y1 - 1976/10
N2 - Unilateral hyphema, hematuria, and ecchymoses developed in a previously healthy 42-year-old woman after the ingestion of aspirin and ethanol. There was no evidence for ocular trauma, disease, or vascular malformation by slit-lamp examination and gonioscopy. Platelet count and coagulation tests were normal. The patient's bleeding time was prolonged and there was impaired platelet aggregation. Delayed (secondary) aggregation in response to collagen, adenosine diphosphate, and epinephrine was decreased, as was aggregation induced by thrombin and serotonin. These data indicate that the qualitative platelet defect was induced by both aspirin and ethanol. Anterior chamber hemorrhage subsided after discontinuation of aspirin and ethanol, and the hyphema subsequently resolved. Bleeding time and platelet aggregation were normal two weeks after the patient's initial presentation. A prolonged bleeding time in association with normal platelet count, prothrombin time, and partial thromboplastin time indicated a qualitative platelet defect, which is most commonly drug-induced. Defective platelet function resulted in spontaneous hyphema.
AB - Unilateral hyphema, hematuria, and ecchymoses developed in a previously healthy 42-year-old woman after the ingestion of aspirin and ethanol. There was no evidence for ocular trauma, disease, or vascular malformation by slit-lamp examination and gonioscopy. Platelet count and coagulation tests were normal. The patient's bleeding time was prolonged and there was impaired platelet aggregation. Delayed (secondary) aggregation in response to collagen, adenosine diphosphate, and epinephrine was decreased, as was aggregation induced by thrombin and serotonin. These data indicate that the qualitative platelet defect was induced by both aspirin and ethanol. Anterior chamber hemorrhage subsided after discontinuation of aspirin and ethanol, and the hyphema subsequently resolved. Bleeding time and platelet aggregation were normal two weeks after the patient's initial presentation. A prolonged bleeding time in association with normal platelet count, prothrombin time, and partial thromboplastin time indicated a qualitative platelet defect, which is most commonly drug-induced. Defective platelet function resulted in spontaneous hyphema.
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U2 - 10.1016/0002-9394(76)90553-5
DO - 10.1016/0002-9394(76)90553-5
M3 - Article
C2 - 970426
AN - SCOPUS:0017162886
VL - 82
SP - 631
EP - 634
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 4
ER -