Abstract
Background: A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees (Pan troglodytes). Methods: We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology. Results: The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, P = 0.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, P = 0.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes. Conclusions: We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 51-58 |
| Number of pages | 8 |
| Journal | Journal of Medical Primatology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
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Keywords
- Ape
- Arteriosclerosis
- Atherosclerosis
- Cardiomyopathy
- Non-human primate
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Spontaneous heart disease in the adult chimpanzee (Pan troglodytes). / Seiler, Brittany M.; Dick, Edward J.; Guardado-Mendoza, Rodolfo; Vandeberg, John L.; Williams, Jeff T.; Mubiru, James N.; Hubbard, Gene B.
In: Journal of Medical Primatology, Vol. 38, No. 1, 2009, p. 51-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spontaneous heart disease in the adult chimpanzee (Pan troglodytes)
AU - Seiler, Brittany M.
AU - Dick, Edward J.
AU - Guardado-Mendoza, Rodolfo
AU - Vandeberg, John L.
AU - Williams, Jeff T.
AU - Mubiru, James N.
AU - Hubbard, Gene B.
PY - 2009
Y1 - 2009
N2 - Background: A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees (Pan troglodytes). Methods: We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology. Results: The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, P = 0.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, P = 0.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes. Conclusions: We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees.
AB - Background: A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees (Pan troglodytes). Methods: We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology. Results: The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, P = 0.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, P = 0.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes. Conclusions: We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees.
KW - Ape
KW - Arteriosclerosis
KW - Atherosclerosis
KW - Cardiomyopathy
KW - Non-human primate
UR - http://www.scopus.com/inward/record.url?scp=58549086376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58549086376&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0684.2008.00307.x
DO - 10.1111/j.1600-0684.2008.00307.x
M3 - Article
C2 - 18671767
AN - SCOPUS:58549086376
VL - 38
SP - 51
EP - 58
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 1
ER -