Spontaneous gallbladder pathology in baboons

J. L. Slingluff; J. T. Williams; L. Blau; A. Blau; E. J. Dick; G. B. Hubbard

doi:10.1111/j.1600-0684.2009.00387.x

Spontaneous gallbladder pathology in baboons

J. L. Slingluff, J. T. Williams, L. Blau, A. Blau, E. J. Dick, G. B. Hubbard

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.

Original language	English (US)
Pages (from-to)	92-96
Number of pages	5
Journal	Journal of medical primatology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0684.2009.00387.x
State	Published - Apr 2010
Externally published	Yes

Keywords

Bile
Cholecystitis
Cholelithiasis
Gallstones
Non-human primate
Papio

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/j.1600-0684.2009.00387.x

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title = "Spontaneous gallbladder pathology in baboons",

abstract = "Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.",

keywords = "Bile, Cholecystitis, Cholelithiasis, Gallstones, Non-human primate, Papio",

author = "Slingluff, {J. L.} and Williams, {J. T.} and L. Blau and A. Blau and Dick, {E. J.} and Hubbard, {G. B.}",

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AU - Williams, J. T.

AU - Blau, L.

AU - Blau, A.

AU - Dick, E. J.

AU - Hubbard, G. B.

PY - 2010/4

Y1 - 2010/4

N2 - Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.

AB - Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.

KW - Bile

KW - Cholecystitis

KW - Cholelithiasis

KW - Gallstones

KW - Non-human primate

KW - Papio

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Spontaneous gallbladder pathology in baboons

Abstract

Keywords

ASJC Scopus subject areas

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