Spontaneous gallbladder pathology in baboons

J. L. Slingluff, J. T. Williams, L. Blau, A. Blau, E. J. Dick, G. B. Hubbard

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalJournal of medical primatology
Volume39
Issue number2
DOIs
StatePublished - Apr 2010

Keywords

  • Bile
  • Cholecystitis
  • Cholelithiasis
  • Gallstones
  • Non-human primate
  • Papio

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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