Spontaneous gallbladder pathology in baboons

J. L. Slingluff, J. T. Williams, L. Blau, A. Blau, E. J. Dick, G. B. Hubbard

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    4 Scopus citations

    Abstract

    Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.

    Original languageEnglish (US)
    Pages (from-to)92-96
    Number of pages5
    JournalJournal of medical primatology
    Volume39
    Issue number2
    DOIs
    StatePublished - Apr 1 2010

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    Keywords

    • Bile
    • Cholecystitis
    • Cholelithiasis
    • Gallstones
    • Non-human primate
    • Papio

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

    Cite this

    Slingluff, J. L., Williams, J. T., Blau, L., Blau, A., Dick, E. J., & Hubbard, G. B. (2010). Spontaneous gallbladder pathology in baboons. Journal of medical primatology, 39(2), 92-96. https://doi.org/10.1111/j.1600-0684.2009.00387.x