Abstract
Background: Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans. Methods: A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP. Results: Ninety-seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%). Conclusion: Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.
Original language | English (US) |
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Pages (from-to) | 92-96 |
Number of pages | 5 |
Journal | Journal of medical primatology |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2010 |
Externally published | Yes |
Keywords
- Bile
- Cholecystitis
- Cholelithiasis
- Gallstones
- Non-human primate
- Papio
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)