Spontaneous and antibody-dependent cellular cytotoxicity by lymphocyte subpopulations in peripheral blood and spleen from adult untreated patients with Hodgkin's disease

S. Gupta, G. Fernandes

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16 Citations (Scopus)

Abstract

Subpopulations of lymphocytes in the peripheral blood and spleen from adult untreated patients with Hodgkin's disease were studied for spontaneous (SCMC) and antibody-dependent cellular cytoxicities (ADCC). Peripheral blood from seven of 24 patients demonstrated abnormally low T cell-mediated SCMC when compared to age- and sex-matched healthy controls. Only two of these patients also demonstrated low T cell ADCC and non-T cell-mediated SCMC and ADCC. T cell ADCC in the peripheral blood of patients with involved spleen was significantly higher (P < 0.05) when compared between peripheral blood and splenic lymphocytes with regard to involvement of spleen by Hodgkin's disease, non-T cell SCMC in the involved spleen was significantly lower (P < 0.05) than their peripheral blood non-T cell SCMC. SCMC and ADCC tended to be higher in patients with stages III and IV of Hodgkin's disease when compared to those with stages I and II. However, the differences were not statistically significant. No direct relationship was observed between T cell SCMC or ADCC and the proportion of T cells with IgG Fc receptors (Tγ). The significance of these observations is discussed.

Original languageEnglish (US)
Pages (from-to)205-214
Number of pages10
JournalClinical and Experimental Immunology
Volume45
Issue number1
StatePublished - 1981
Externally publishedYes

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Lymphocyte Subsets
Hodgkin Disease
Spleen
T-Lymphocytes
Antibodies
Antibody-Dependent Cell Cytotoxicity
IgG Receptors
Fc Receptors
Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "Subpopulations of lymphocytes in the peripheral blood and spleen from adult untreated patients with Hodgkin's disease were studied for spontaneous (SCMC) and antibody-dependent cellular cytoxicities (ADCC). Peripheral blood from seven of 24 patients demonstrated abnormally low T cell-mediated SCMC when compared to age- and sex-matched healthy controls. Only two of these patients also demonstrated low T cell ADCC and non-T cell-mediated SCMC and ADCC. T cell ADCC in the peripheral blood of patients with involved spleen was significantly higher (P < 0.05) when compared between peripheral blood and splenic lymphocytes with regard to involvement of spleen by Hodgkin's disease, non-T cell SCMC in the involved spleen was significantly lower (P < 0.05) than their peripheral blood non-T cell SCMC. SCMC and ADCC tended to be higher in patients with stages III and IV of Hodgkin's disease when compared to those with stages I and II. However, the differences were not statistically significant. No direct relationship was observed between T cell SCMC or ADCC and the proportion of T cells with IgG Fc receptors (Tγ). The significance of these observations is discussed.",
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AU - Gupta, S.

AU - Fernandes, G.

PY - 1981

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N2 - Subpopulations of lymphocytes in the peripheral blood and spleen from adult untreated patients with Hodgkin's disease were studied for spontaneous (SCMC) and antibody-dependent cellular cytoxicities (ADCC). Peripheral blood from seven of 24 patients demonstrated abnormally low T cell-mediated SCMC when compared to age- and sex-matched healthy controls. Only two of these patients also demonstrated low T cell ADCC and non-T cell-mediated SCMC and ADCC. T cell ADCC in the peripheral blood of patients with involved spleen was significantly higher (P < 0.05) when compared between peripheral blood and splenic lymphocytes with regard to involvement of spleen by Hodgkin's disease, non-T cell SCMC in the involved spleen was significantly lower (P < 0.05) than their peripheral blood non-T cell SCMC. SCMC and ADCC tended to be higher in patients with stages III and IV of Hodgkin's disease when compared to those with stages I and II. However, the differences were not statistically significant. No direct relationship was observed between T cell SCMC or ADCC and the proportion of T cells with IgG Fc receptors (Tγ). The significance of these observations is discussed.

AB - Subpopulations of lymphocytes in the peripheral blood and spleen from adult untreated patients with Hodgkin's disease were studied for spontaneous (SCMC) and antibody-dependent cellular cytoxicities (ADCC). Peripheral blood from seven of 24 patients demonstrated abnormally low T cell-mediated SCMC when compared to age- and sex-matched healthy controls. Only two of these patients also demonstrated low T cell ADCC and non-T cell-mediated SCMC and ADCC. T cell ADCC in the peripheral blood of patients with involved spleen was significantly higher (P < 0.05) when compared between peripheral blood and splenic lymphocytes with regard to involvement of spleen by Hodgkin's disease, non-T cell SCMC in the involved spleen was significantly lower (P < 0.05) than their peripheral blood non-T cell SCMC. SCMC and ADCC tended to be higher in patients with stages III and IV of Hodgkin's disease when compared to those with stages I and II. However, the differences were not statistically significant. No direct relationship was observed between T cell SCMC or ADCC and the proportion of T cells with IgG Fc receptors (Tγ). The significance of these observations is discussed.

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