Subpopulations of lymphocytes in the peripheral blood and spleen from adult untreated patients with Hodgkin's disease were studied for spontaneous (SCMC) and antibody-dependent cellular cytoxicities (ADCC). Peripheral blood from seven of 24 patients demonstrated abnormally low T cell-mediated SCMC when compared to age- and sex-matched healthy controls. Only two of these patients also demonstrated low T cell ADCC and non-T cell-mediated SCMC and ADCC. T cell ADCC in the peripheral blood of patients with involved spleen was significantly higher (P < 0.05) when compared between peripheral blood and splenic lymphocytes with regard to involvement of spleen by Hodgkin's disease, non-T cell SCMC in the involved spleen was significantly lower (P < 0.05) than their peripheral blood non-T cell SCMC. SCMC and ADCC tended to be higher in patients with stages III and IV of Hodgkin's disease when compared to those with stages I and II. However, the differences were not statistically significant. No direct relationship was observed between T cell SCMC or ADCC and the proportion of T cells with IgG Fc receptors (Tγ). The significance of these observations is discussed.
|Original language||English (US)|
|Number of pages||10|
|Journal||Clinical and Experimental Immunology|
|State||Published - Jan 1 1981|
ASJC Scopus subject areas
- Immunology and Allergy