TY - JOUR
T1 - Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations
AU - Gupta, S.
AU - Fernandes, G.
AU - Nair, M.
AU - Good, R. A.
PY - 1978
Y1 - 1978
N2 - Human peripheral blood non-T cells, T cells, and their subpopulations (Tμ, Tγ, T∅, Tγ-depleted cells, and Tμ-depleted cells) were assayed for their capacity to mediate spontaneous lymphocyte-mediated cytotoxicity (SLMC) or natural killer activity against K562 tumor cell line and antibody-dependent cellular cytotoxicity (ADCC) against chicken erythrocytes coated with antibody. Non-T cells, unseparated T cells, Tγ cells, and Tμ-depleted (Tγ-enriched) cells were found to have both SLMC (N(K) activity) and ADCC. Tμ, T∅ and Tγ-depleted cells had minimal or no SLMC and ADCC activity. This study demonstrated that SLMC and ADCC activity in T cells is mediated by Tγ cell subpopulations. These two cytotoxic reactions were either mediated by two distinct subsets of Tγ-cells or by a single effector cell using two different mechanisms.
AB - Human peripheral blood non-T cells, T cells, and their subpopulations (Tμ, Tγ, T∅, Tγ-depleted cells, and Tμ-depleted cells) were assayed for their capacity to mediate spontaneous lymphocyte-mediated cytotoxicity (SLMC) or natural killer activity against K562 tumor cell line and antibody-dependent cellular cytotoxicity (ADCC) against chicken erythrocytes coated with antibody. Non-T cells, unseparated T cells, Tγ cells, and Tμ-depleted (Tγ-enriched) cells were found to have both SLMC (N(K) activity) and ADCC. Tμ, T∅ and Tγ-depleted cells had minimal or no SLMC and ADCC activity. This study demonstrated that SLMC and ADCC activity in T cells is mediated by Tγ cell subpopulations. These two cytotoxic reactions were either mediated by two distinct subsets of Tγ-cells or by a single effector cell using two different mechanisms.
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U2 - 10.1073/pnas.75.10.5137
DO - 10.1073/pnas.75.10.5137
M3 - Article
C2 - 311006
AN - SCOPUS:0018146211
SN - 0027-8424
VL - 75
SP - 5137
EP - 5141
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -