Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations

S. Gupta, G. Fernandes, M. Nair, R. A. Good

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Human peripheral blood non-T cells, T cells, and their subpopulations (Tμ, Tγ, T∅, Tγ-depleted cells, and Tμ-depleted cells) were assayed for their capacity to mediate spontaneous lymphocyte-mediated cytotoxicity (SLMC) or natural killer activity against K562 tumor cell line and antibody-dependent cellular cytotoxicity (ADCC) against chicken erythrocytes coated with antibody. Non-T cells, unseparated T cells, Tγ cells, and Tμ-depleted (Tγ-enriched) cells were found to have both SLMC (N(K) activity) and ADCC. Tμ, T∅ and Tγ-depleted cells had minimal or no SLMC and ADCC activity. This study demonstrated that SLMC and ADCC activity in T cells is mediated by Tγ cell subpopulations. These two cytotoxic reactions were either mediated by two distinct subsets of Tγ-cells or by a single effector cell using two different mechanisms.

Original languageEnglish (US)
Pages (from-to)5137-5141
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number10
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • General

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