Split-liver transplantation: Results of statewide usage of the right trisegmental graft

Kenneth Washburn, Glenn A Halff, Luis Mieles, Robert Goldstein, John A. Goss

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Split-liver transplantation (SLT) effectively expands the cadaveric donor pool for children. The remaining right trisegmental (RTS) graft can be transplanted into adults. Limited information exists regarding the outcomes of RTS allografts. Sixty-five RTS graft recipients from five adult transplant programs in Texas were identified. Donor and recipient information were analyzed retrospectively. Most livers (75%) were originally allocated to pediatric recipients. Liver splitting occurred via the in situ (72%) and ex situ (28%) techniques. Arterial reconstruction of RTS grafts was common (52%). Patient and graft survival at 3 months were comparable for the in situ and ex situ techniques (p = 0.2). Cox regression showed only in situ splitting to be a predictor of outcome longer than 3 months posttransplant. Sharing of grafts between centers was frequent (37% of total). One-year patient and allograft survival (87.1% and 85.4%) were excellent with no cases of primary nonfunction. SLT consistently generates two functional liver allografts with excellent recipient survival. In situ splitting of the liver is the preferred technique. Decreased survival is observed with RTS graft use in higher risk recipients. Broader application of SLT with increased sharing is feasible and safely expands the number of liver allografts that can be transplanted.

Original languageEnglish (US)
Pages (from-to)1652-1659
Number of pages8
JournalAmerican Journal of Transplantation
Volume5
Issue number7
DOIs
StatePublished - Jul 2005

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Liver Transplantation
Transplants
Allografts
Liver
Tissue Donors
Survival
Graft Survival
Pediatrics

Keywords

  • Split-liver transplantation

ASJC Scopus subject areas

  • Immunology

Cite this

Split-liver transplantation : Results of statewide usage of the right trisegmental graft. / Washburn, Kenneth; Halff, Glenn A; Mieles, Luis; Goldstein, Robert; Goss, John A.

In: American Journal of Transplantation, Vol. 5, No. 7, 07.2005, p. 1652-1659.

Research output: Contribution to journalArticle

Washburn, Kenneth ; Halff, Glenn A ; Mieles, Luis ; Goldstein, Robert ; Goss, John A. / Split-liver transplantation : Results of statewide usage of the right trisegmental graft. In: American Journal of Transplantation. 2005 ; Vol. 5, No. 7. pp. 1652-1659.
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