Splanchnic perfusion evaluation during hemorrhage and resuscitation with gastric near-infrared spectroscopy

Stephen M. Cohn, J. Esteban Varela, Giovanni Giannotti, Matthew O. Dolich, Margaret Brown, Ara Feinstein, Mark G. McKenney, Paul Spalding

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Objective: The purpose of this study was to use a prototype side-illuminating near-infrared spectroscopy (NIRS) nasogastric probe to continuously measure changes in gastric tissue oxygen saturation (Sto2) in a pig hemorrhage model. Methods: Swine (n = 12; 6 per group) underwent laparotomy and placement of a gastric NIRS probe, jejunal tonometer, superior mesenteric artery (SMA) flow probe, and a portal vein catheter. Animals underwent hemorrhage (28 mL/kg) t = 0 to 20 minutes (where t = time). Pigs in group I were resuscitated (t = 20-40 minutes) with lactated Ringer's solution (84 mL/kg), whereas group II had no resuscitation. Results: A significant decrease in mean arterial pressure and SMA flow was observed after hemorrhage. SMA flow significantly correlated in group I with both NIRS Sto2 (r = 0.58, p = 0.0001) and regional CO2 (r = -0.54, p = 0.0001). In group II, superior mesenteric flow correlated with NIRS Sto2 (r = 0.30, p = 0.03), but not regional CO2 (r = -0.23, p = 0.09). Conclusion: Direct measurement of tissue oxygen saturation with a prototype side-illuminating near-infrared spectroscopy gastric probe appeared to rapidly reflect changes in splanchnic perfusion.

Original languageEnglish (US)
Pages (from-to)629-635
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume50
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Hemorrhagic shock
  • Near-infrared spectroscopy
  • Resuscitation
  • Splanchnic perfusion

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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    Cohn, S. M., Varela, J. E., Giannotti, G., Dolich, M. O., Brown, M., Feinstein, A., McKenney, M. G., & Spalding, P. (2001). Splanchnic perfusion evaluation during hemorrhage and resuscitation with gastric near-infrared spectroscopy. Journal of Trauma - Injury, Infection and Critical Care, 50(4), 629-635. https://doi.org/10.1097/00005373-200104000-00006