TY - JOUR
T1 - Splanchnic and peripheral disposal of oral glucose in man
AU - Katz, L. D.
AU - Glickman, M. G.
AU - Rapoport, S.
AU - Ferrannin, E.
AU - DeFronzo, R. A.
PY - 1983
Y1 - 1983
N2 - Oral glucose (92 g) was administered to 22 healthy, young volunteers undergoing hepatic vein catheterization, and net splanchnic glucose output (SGO) was measured during the basal period and for 4 h after glucose ingestion. In the basal state , SGO averaged 1.90 ± 0.11 mg/min.kg. After glucose, SGO rose to a peak value of 6.65 ± 0.83 mg/min.kg at 39 min and returned to baseline by 3 h. Total SGO over 4 h was 69 ± 4 g; assuming complete absorption of the load, this amount represented 75% of the oral glucose. In a subgroup of six subjects, leg glucose uptake was simultaneously quantitated by femoral vein catheterization and leg blood flow measurement. In the post-absorptive stage, glucose uptake by one leg was 24 ± 8 mg/min and increased to a mean value of 76 ± 7 mg/min during the 4 h after glucose ingestion. Overall, 18 ± 2 g/4 h of glucose were taken up by one leg, which extrapolates to a total body muscle uptake of 65 ± 4 g over 4 h. We conclude that in normal man, well over 2/3 of an oral glucose load escapes splanchnic removal, and that the peripheral tissues quantitatively play the dominant role in glucose disposal.
AB - Oral glucose (92 g) was administered to 22 healthy, young volunteers undergoing hepatic vein catheterization, and net splanchnic glucose output (SGO) was measured during the basal period and for 4 h after glucose ingestion. In the basal state , SGO averaged 1.90 ± 0.11 mg/min.kg. After glucose, SGO rose to a peak value of 6.65 ± 0.83 mg/min.kg at 39 min and returned to baseline by 3 h. Total SGO over 4 h was 69 ± 4 g; assuming complete absorption of the load, this amount represented 75% of the oral glucose. In a subgroup of six subjects, leg glucose uptake was simultaneously quantitated by femoral vein catheterization and leg blood flow measurement. In the post-absorptive stage, glucose uptake by one leg was 24 ± 8 mg/min and increased to a mean value of 76 ± 7 mg/min during the 4 h after glucose ingestion. Overall, 18 ± 2 g/4 h of glucose were taken up by one leg, which extrapolates to a total body muscle uptake of 65 ± 4 g over 4 h. We conclude that in normal man, well over 2/3 of an oral glucose load escapes splanchnic removal, and that the peripheral tissues quantitatively play the dominant role in glucose disposal.
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U2 - 10.2337/diab.32.7.675
DO - 10.2337/diab.32.7.675
M3 - Article
C2 - 6862113
AN - SCOPUS:0020568971
VL - 37
SP - 675
EP - 679
JO - Research in Microbiology
JF - Research in Microbiology
SN - 0923-2508
IS - 7 I
ER -