Spiral waves and intracellular calcium signalling

JD D. Lechleiter, DE E. Clapham

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Confocal imaging of intracellular Ca2+ brings a new level of resolution to the study of hormonal control of intracellular Ca2+ release. This approach has demonstrated the existence of pulsatile circular and spiral waves of Ca+ release induced by receptor activation. The data obtained by confocal imaging support a new framework for understanding intracellular Ca2+ signalling. The goal of this chapter is to review our data on the complexity of intracellular Ca2+ release in Xenopus oocytes, introduce the concept of Ca2+ excitability as a model for Ca2+ release and discuss the implications for encoding intracellular signal information.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalJournal of Physiology - Paris
Issue number1-3
StatePublished - 1992
Externally publishedYes


  • IP
  • Xenopus oocytes
  • confocal microscopy
  • excitable media

ASJC Scopus subject areas

  • Physiology (medical)
  • General Neuroscience


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