Spindle cell reaction to nontuberculous mycobacteriosis in AIDS mimicking a spindle cell neoplasm - Evidence for dual histiocytic and fibroblast-like characteristics of spindle cells

Margaret Brandwein, Ho Soon H. Choi, James Strauchen, Mark Stoler, Jaishree Jagirdar

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

We report 5 patients with AIDS who had an unusual spindle cell proliferation in the lymph nodes and skin caused by nontuberculous mycobacteriosis. The spindle cell proliferation in these tissues may mimic a spindle cell neoplasm and pose a diagnostic problem if an infectious aetiology is not suspected. The fibroblast-like spindle cells contained numerous acid fast bacilli. They were strongly positive for antibody markers of monocyte/macrophage and leukocyte derivation: Leu M3, Mo-9, T-200, and HLA-DR, and variably positive for alpha-1 anti-chymotrypsin and lysozyme. Ultrastructurally these spindle cells were predominantly fibroblast-like with poorly developed features of macrophages. These results reveal the dual macrophage and fibroblastic character of the spindle cells and probably imply a functional differentiation rather than a histogenetic one.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Volume416
Issue number4
DOIs
StatePublished - Jul 1 1990

Keywords

  • AIDS
  • Facultative fibroblasts
  • Mycobacteria
  • Spindle cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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