Spinal cord metastasis in small cell carcinoma of the lung

Paul Holoye; Joseph Libnoch; James Cox; Larry Kun; Roger Byhardt; Urias Almagro; Steve McClelland; Kedar Chintapali

doi:10.1016/0360-3016(84)90053-1

Spinal cord metastasis in small cell carcinoma of the lung

Paul Holoye, Joseph Libnoch, James Cox, Larry Kun, Roger Byhardt, Urias Almagro, Steve McClelland, Kedar Chintapali

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.

Original language	English (US)
Pages (from-to)	349-356
Number of pages	8
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0360-3016(84)90053-1
State	Published - Mar 1984
Externally published	Yes

Keywords

Recurrence
Small cell lung cancer
Spinal cord

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(84)90053-1

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title = "Spinal cord metastasis in small cell carcinoma of the lung",

abstract = "Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.",

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AU - Holoye, Paul

AU - Libnoch, Joseph

AU - Cox, James

AU - Kun, Larry

AU - Byhardt, Roger

AU - Almagro, Urias

AU - McClelland, Steve

AU - Chintapali, Kedar

PY - 1984/3

Y1 - 1984/3

N2 - Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.

AB - Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.

KW - Recurrence

KW - Small cell lung cancer

KW - Spinal cord

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Spinal cord metastasis in small cell carcinoma of the lung

Abstract

Keywords

ASJC Scopus subject areas

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