Spermatogenesis as a model system for developmental analysis of regulatory mechanisms associated with tissue-specific gene expression

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33 Scopus citations

Abstract

Spermatogenesis is a complex system leading to the formation of male gametes. Development of the spermatogenic cell lineage occurs throughout most of the pre- and post-natal lifetime of male mammals, and involves progression through a well-characterized series of stages and cell types. This progression is based on programmed gene expression. The mechanisms by which this tissue-, cell-type, and developmental-stage specific gene expression is regulated form the focus of an active area of investigation. In this review, I will summarize our efforts to elucidate these mechanisms through molecular analyses of the uniquely accessible mouse spermatogenic cell lineage.

Original languageEnglish (US)
Pages (from-to)459-466
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume9
Issue number4
DOIs
StatePublished - Aug 1998
Externally publishedYes

Keywords

  • Chromatin
  • DNA methylation
  • Gene regulation
  • Promoters
  • Spermatogenesis

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

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