TY - JOUR
T1 - Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection
AU - Marshall, Douglas W.
AU - Brey, Robin L.
AU - Cahill, William T.
AU - Houk, Richard W.
AU - Zajac, Robert A.
AU - Boswell, Richard N.
PY - 1988/9
Y1 - 1988/9
N2 - This report summarizes the results of neurologic and cerebrospinal fluid (CSF) study findings in over 400 of the 649 human immunodeficiency virus-infected US Air Force personnel, evaluated as of Dec 31, 1987. Eighty percent of these patients were entirely asymptomatic and immunologically normal, 13% had low T-helper lymphocyte counts and/or cutaneous anergy, and only 7% had opportunistic infection. Sixty-three percent of all patients had some CSF abnormality. Sixty percent of the asymptomatic group had at least one abnormal result, over 25% had three or four CSF abnormalities, and over 7% had five or six abnormal values. When patients with evidence of blood-brain barrier leak were excluded, significant differences were seen between disease groups with regard to CSF glucose, CSF IgG levels, and CSF IgG synthesis. No human immunodeficiency virus-related central nervous system abnormalities were found on neurologic examination in immunologically intact asymptomatic patients regardless of CSF findings. No clear-cut predictor of impending central nervous system complications has, as yet, been identified from the CSF parameters studied.
AB - This report summarizes the results of neurologic and cerebrospinal fluid (CSF) study findings in over 400 of the 649 human immunodeficiency virus-infected US Air Force personnel, evaluated as of Dec 31, 1987. Eighty percent of these patients were entirely asymptomatic and immunologically normal, 13% had low T-helper lymphocyte counts and/or cutaneous anergy, and only 7% had opportunistic infection. Sixty-three percent of all patients had some CSF abnormality. Sixty percent of the asymptomatic group had at least one abnormal result, over 25% had three or four CSF abnormalities, and over 7% had five or six abnormal values. When patients with evidence of blood-brain barrier leak were excluded, significant differences were seen between disease groups with regard to CSF glucose, CSF IgG levels, and CSF IgG synthesis. No human immunodeficiency virus-related central nervous system abnormalities were found on neurologic examination in immunologically intact asymptomatic patients regardless of CSF findings. No clear-cut predictor of impending central nervous system complications has, as yet, been identified from the CSF parameters studied.
UR - http://www.scopus.com/inward/record.url?scp=0023678884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023678884&partnerID=8YFLogxK
U2 - 10.1001/archneur.1988.00520330032007
DO - 10.1001/archneur.1988.00520330032007
M3 - Article
C2 - 2970837
AN - SCOPUS:0023678884
VL - 45
SP - 954
EP - 958
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 9
ER -