Specification of spermatogonial stem cells

Research output: Chapter in Book/Report/Conference proceedingChapter


Spermatogenesis is an ongoing differentiation process that occurs in the seminiferous epithelium in the testis in males to produce spermatozoa (sperm) and is sustained by a tissue-specific stem cell termed the “spermatogonial stem cell.” Spermatogonial stem cells (SSCs) must maintain the spermatogenic stem cell population via self-renewal while also providing an ongoing supply of cells that enter the terminal differentiation process of spermatogenesis. This article describes current evidence and theories regarding the manner in which a unique subset of developing spermatogonia become allocated to form the SSCs.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
Number of pages2
ISBN (Electronic)9780128151457
StatePublished - Jan 1 2018
Externally publishedYes


  • Apoptosis
  • Asymmetric cell division
  • Cell death
  • Cell-type allocation
  • Cell-type specification
  • Development
  • Differentiating spermatogonia
  • Differentiation
  • Epigenetic programming
  • Gametogenesis
  • Germ cells
  • Predetermination
  • Progenitor spermatogonia
  • Selection
  • Self-renewal
  • Seminiferous epithelium
  • Spermatogenesis
  • Spermatogonial transplantation
  • Testis
  • Tissue-specific stem cells
  • Undifferentiated spermatogonia

ASJC Scopus subject areas

  • General Medicine


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