Specific Lactobacillus species differentially activate Toll-like receptors and downstream signals in dendritic cells

Mansour Mohamadzadeh, Todd R. Klaenhammer

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Dendritic cells (DCs) regulate mucosal T-cell immunity and encounter several distinct bacteria of the gut flora, including lactobacilli. Gram-positive lactobacilli have been suggested to play an important role in exerting adjuvanticity effects on innate immune cells at mucosal sites. Aims & methods: In the present report, we studied the effects of specific Lactobacillus species on human monocyte derived DCs. Results: We show that lactobacilli activate DCs by differentially inducing the expression of Toll-like receptors and bioactive IL-12 in Lactobacillus-treated DCs. Further, these specific Lactobacillus spp. did not activate the phosphorylation of p38 MAPK, which might be a downstream effect of the remarkable capacity of lactobacilli to induce IL-12 in DCs that skew T cells significantly toward an IFN-γ-secreting Th1 response. Conclusion: These results highlight an important role of specific Lactobacillus spp. as adjuvants in triggering DC function, which in turn may determine the immunological outcome in an environment wherein innate cells reside.

Original languageEnglish (US)
Pages (from-to)1155-1164
Number of pages10
JournalExpert Review of Vaccines
Volume7
Issue number8
DOIs
StatePublished - Oct 2008
Externally publishedYes

Keywords

  • Adjuvant
  • Dendritic cell
  • Lactobacillus
  • MAP kinase
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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