Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: An early event in disease pathogenesis

Hua Cheng, Miao Wang, Jian Liang Li, Nigel J. Cairns, Xianlin Han

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

To explore the hypothesis that alterations in cellular membrane lipids are present at the stage of pre-clinical Alzheimer's disease (AD) (i.e., cognitively normal at death, but with AD neuropathology), we performed targeted shotgun lipidomics of lipid extracts from post-mortem brains of subjects with pre-clinical AD. We found sulfatide levels were significantly lower in subjects with pre-clinical AD compared to those without AD neuropathology. We also found that the level of ethanolamine glycerophospholipid was marginally lower at this stage of AD, whereas changes of the ceramide levels were undetectable with the available samples. These results indicate that cellular membrane defects are present at the earliest stages of AD pathogenesis and also suggest that sulfatide loss is among the earliest events of AD development, while alterations in the levels of ethanolamine glycerophospholipid and ceramide occur relatively later in disease. To determine lipid changes at the stage of pre-clinical Alzheimer's disease (AD) (i.e., cognitively normal at death, but with AD neuropathology), we performed lipidomics analysis and found that sulfatide levels were significantly lower in subjects with pre-clinical AD compared to those without AD neuropathology. The results suggest that sulfatide loss is among the earliest events of AD development.

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalJournal of neurochemistry
Volume127
Issue number6
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

    Fingerprint

Keywords

  • ceramide
  • membrane lipids
  • plasmalogen
  • pre-clinical Alzheimer's disease
  • shotgun lipidomics
  • sulfatide

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this