Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults

Monique Bouvier, Wei Ju Chen, John C. Arnold, Mary P. Fairchok, Patrick J. Danaher, Tahaniyat Lalani, Leslie Malone, Deepika Mor, Michelande Ridoré, Timothy H. Burgess, Eugene V. Millar

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalInfluenza and other Respiratory Viruses
Volume12
Issue number2
DOIs
StatePublished - Mar 2018

Keywords

  • clinical characteristics
  • coronavirus
  • influenza-like illness

ASJC Scopus subject areas

  • Epidemiology
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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