Species differences of the thyroid protein kinase C heterogeneity

D. Feliers, M. Pavlovic-Hournac

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Protein kinase C (PKC), the mediator of the phosphoinositide transduction pathway, is a family of at least 11 isozymes and its heterogeneity has been described in many tissues and cells. We studied here the heterogeneity of PKC in thyroid glands from three different species, rat, pig, and dog. By combining immunological and biochemical approaches, we identified in rat thyroids, the PKCα, βII, δ, ε, and ζ subspecies, in pig thyroids, the α, ε, and ζ isozymes, and in dog thyroids, only the α and ζ isozymes. The observed species differences of the thyroid gland PKC heterogeneity could be related to the reported species differences in the activation of the phosphoinositide regulatory cascade by TSH and other thyroid cell regulators.

Original languageEnglish (US)
Pages (from-to)459-465
Number of pages7
Issue number4
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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