Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

Caroline André, Jason C. O'Connor, Keith W. Kelley, Jacques Lestage, Robert Dantzer, Nathalie Castanon

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression in the brain in response to intraperitoneal lipopolysaccharide injection in mice, we report a time-dependent induction of IDO expression in both the hippocampus and hypothalamus that was associated with a specific structure-dependent expression of proinflammatory cytokines, particularly interferon-γ. This study suggests that different mechanisms regulate the activation of IDO by lipopolysaccharide in various brain structures.

Original languageEnglish (US)
Pages (from-to)90-99
Number of pages10
JournalJournal of Neuroimmunology
Volume200
Issue number1-2
DOIs
StatePublished - Aug 30 2008
Externally publishedYes

Keywords

  • Hippocampus
  • Hypothalamus
  • Interferon-γ
  • Interleukin-1
  • Interleukin-6
  • Tumor-necrosis factor-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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