Abstract
The mechanisms underlying in vivo activation of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme that mediates in the brain the induction of depressive-like behavior by peripheral innate immune system stimulation are still poorly understood. By monitoring how cytokines parallel IDO mRNA expression in the brain in response to intraperitoneal lipopolysaccharide injection in mice, we report a time-dependent induction of IDO expression in both the hippocampus and hypothalamus that was associated with a specific structure-dependent expression of proinflammatory cytokines, particularly interferon-γ. This study suggests that different mechanisms regulate the activation of IDO by lipopolysaccharide in various brain structures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 90-99 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 200 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Aug 30 2008 |
| Externally published | Yes |
Keywords
- Hippocampus
- Hypothalamus
- Interferon-γ
- Interleukin-1
- Interleukin-6
- Tumor-necrosis factor-α
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
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Cite this
André, C., O'Connor, J. C., Kelley, K. W., Lestage, J., Dantzer, R., & Castanon, N. (2008). Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. Journal of Neuroimmunology, 200(1-2), 90-99. https://doi.org/10.1016/j.jneuroim.2008.06.011