Spatial variation in osteonal bone properties relative to tissue and animal age

Samuel Gourion-Arsiquaud, Jayme C. Burket, Lorena M. Havill, Edward DiCarlo, Stephen B. Doty, Richard Mendelsohn, Marjolein C H Van Der Meulen, Adele L. Boskey

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Little is known about osteonal bone mineral and matrix properties, although these properties are of major importance for the understanding of bone alterations related to age and bone diseases such as osteoporosis. During aging, bone undergoes modifications that compromise their structural integrity as shown clinically by the increase of fracture incidence with age. Based on Fourier transform infrared (FTIR) analysis from baboons between 0 and 32 yr of age, consistent systematic variations in bone properties as a function of tissue age are reported within osteons. The patterns observed were independent of animal age and positively correlated with bone tissue elastic behavior measured by nano-indentation. As long as tissue age is expressed as a percentage of the entire osteon radius, osteonal analyses can be used to characterize disease changes independent of the size of the osteon. These mineral and matrix analyses can be used to explain bone fragility. The mineral content (mineral-to-matrix ratio) was correlated with the animal age in both old (interstitial) and newly formed bone tissue, showing for the first time that age-related changes in BMC can be explain by an alteration in the mineralization process itself and not only by an imbalance in the remodeling process.

Original languageEnglish (US)
Pages (from-to)1271-1281
Number of pages11
JournalJournal of Bone and Mineral Research
Volume24
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Haversian System
Bone and Bones
Minerals
Bone Matrix
Papio
Bone Diseases
Fourier Analysis
Osteoporosis
Incidence

Keywords

  • Aging
  • Bone quality
  • Fourier transform infrared imaging
  • Fourier transform infrared microspectroscopy
  • Nonhuman primate model
  • Osteon

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Gourion-Arsiquaud, S., Burket, J. C., Havill, L. M., DiCarlo, E., Doty, S. B., Mendelsohn, R., ... Boskey, A. L. (2009). Spatial variation in osteonal bone properties relative to tissue and animal age. Journal of Bone and Mineral Research, 24(7), 1271-1281. https://doi.org/10.1359/jbmr.090201

Spatial variation in osteonal bone properties relative to tissue and animal age. / Gourion-Arsiquaud, Samuel; Burket, Jayme C.; Havill, Lorena M.; DiCarlo, Edward; Doty, Stephen B.; Mendelsohn, Richard; Van Der Meulen, Marjolein C H; Boskey, Adele L.

In: Journal of Bone and Mineral Research, Vol. 24, No. 7, 07.2009, p. 1271-1281.

Research output: Contribution to journalArticle

Gourion-Arsiquaud, S, Burket, JC, Havill, LM, DiCarlo, E, Doty, SB, Mendelsohn, R, Van Der Meulen, MCH & Boskey, AL 2009, 'Spatial variation in osteonal bone properties relative to tissue and animal age', Journal of Bone and Mineral Research, vol. 24, no. 7, pp. 1271-1281. https://doi.org/10.1359/jbmr.090201
Gourion-Arsiquaud S, Burket JC, Havill LM, DiCarlo E, Doty SB, Mendelsohn R et al. Spatial variation in osteonal bone properties relative to tissue and animal age. Journal of Bone and Mineral Research. 2009 Jul;24(7):1271-1281. https://doi.org/10.1359/jbmr.090201
Gourion-Arsiquaud, Samuel ; Burket, Jayme C. ; Havill, Lorena M. ; DiCarlo, Edward ; Doty, Stephen B. ; Mendelsohn, Richard ; Van Der Meulen, Marjolein C H ; Boskey, Adele L. / Spatial variation in osteonal bone properties relative to tissue and animal age. In: Journal of Bone and Mineral Research. 2009 ; Vol. 24, No. 7. pp. 1271-1281.
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