Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats

Fabio Antônio Borges Vigil, Ieda de Fátima Oliveira-Silva, Lívia Freire Ferreira, Silvia Rejane Castanheira Pereira, Angela Maria Ribeiro

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.

Original languageEnglish (US)
Pages (from-to)140-142
Number of pages3
JournalBehavioural Brain Research
Volume210
Issue number1
DOIs
StatePublished - Jun 2010
Externally publishedYes

Keywords

  • 5-HIAA
  • Morris water maze
  • Pyrithiamine
  • Rats
  • Spatial learning and memory
  • Thalamus
  • Thiamine deficiency

ASJC Scopus subject areas

  • Behavioral Neuroscience

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