Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2 Akita mouse model of diabetes

Nikolay P. Akimov, René C. Rentería

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2 Akita mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2 Akita mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalBehavioural Brain Research
Volume226
Issue number2
DOIs
StatePublished - Jan 15 2012

Keywords

  • Diabetes
  • Diabetic retinopathy
  • Ins2 mouse
  • Optokinetic response
  • Retina
  • Vision

ASJC Scopus subject areas

  • Behavioral Neuroscience

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