Spatial dose distributions in solid tumors from 186Re transported by liposomes using HS radiochromic media

Luis A. Medina, Beth Goins, Mercedes Rodríguez-Villafuerte, Ande Bao, Arnulfo Martínez-Davalos, Vibhudutta Awasthi, Olga O. Galván, Cristina Santoyo, William T Phillips, María Ester Brandan

Research output: Contribution to journalArticle

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Abstract

Purpose: A procedure for the measurement of spatial dose rate distribution of beta particles emitted by 186Re-liposomes in tumoral tissue, using HS GafChromic films, is presented. Methods: HNSCC xenografts were intratumorally injected with 3.7 or 11.1 MBq of 186Re-liposomes, and planar gamma camera images were acquired to determine the liposome retention in the tumor. After imaging, rats were sacrificed and tumors were excised and processed in slices; HS film sections were placed between slices and the tumor lobe was reassembled. Tumors and films were kept in the dark at 4°C for 18 h. After irradiation, films were removed and response was read using a transmission scanner. Films were analyzed to determine two-dimensional spatial dose rate distributions and cumulative dose volume histograms. Dose rate distributions were quantified using a 60Co calibration curve, the 186Re physical half-life, and a perturbation factor that takes into account the effect of the film protective layer. Results: Dose rate distributions are highly heterogeneous with maximal dose rates about 0.4 Gy h-1 in tumors injected with 3.7 MBq and 1.3 Gy h-1 in tumors injected with 11.1 MBq. Dose volume histograms showed dose distributed in more than 95% and 80% of the tumor when injected with the lower and the higher activity, respectively. Conclusion: The described procedures and techniques have shown the potential and utility of HS GafChromic film for determination of dose rate distributions in solid tumors injected intratumorally with 186Re-liposomes. The film's structure and the liposomes' biodistribution must be taken into account to obtain quantitative dose measurements.

Original languageEnglish (US)
Pages (from-to)1039-1049
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume34
Issue number7
DOIs
StatePublished - Jul 2007

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Liposomes
Neoplasms
Beta Particles
Gamma Cameras
Heterografts
Calibration
Half-Life

Keywords

  • Re
  • HS Gafchromic film
  • Intratumoral dosimetry
  • Liposomes
  • MC simulation
  • Radionuclide therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Medina, L. A., Goins, B., Rodríguez-Villafuerte, M., Bao, A., Martínez-Davalos, A., Awasthi, V., ... Brandan, M. E. (2007). Spatial dose distributions in solid tumors from 186Re transported by liposomes using HS radiochromic media. European Journal of Nuclear Medicine and Molecular Imaging, 34(7), 1039-1049. https://doi.org/10.1007/s00259-006-0297-x

Spatial dose distributions in solid tumors from 186Re transported by liposomes using HS radiochromic media. / Medina, Luis A.; Goins, Beth; Rodríguez-Villafuerte, Mercedes; Bao, Ande; Martínez-Davalos, Arnulfo; Awasthi, Vibhudutta; Galván, Olga O.; Santoyo, Cristina; Phillips, William T; Brandan, María Ester.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 34, No. 7, 07.2007, p. 1039-1049.

Research output: Contribution to journalArticle

Medina, LA, Goins, B, Rodríguez-Villafuerte, M, Bao, A, Martínez-Davalos, A, Awasthi, V, Galván, OO, Santoyo, C, Phillips, WT & Brandan, ME 2007, 'Spatial dose distributions in solid tumors from 186Re transported by liposomes using HS radiochromic media', European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 7, pp. 1039-1049. https://doi.org/10.1007/s00259-006-0297-x
Medina, Luis A. ; Goins, Beth ; Rodríguez-Villafuerte, Mercedes ; Bao, Ande ; Martínez-Davalos, Arnulfo ; Awasthi, Vibhudutta ; Galván, Olga O. ; Santoyo, Cristina ; Phillips, William T ; Brandan, María Ester. / Spatial dose distributions in solid tumors from 186Re transported by liposomes using HS radiochromic media. In: European Journal of Nuclear Medicine and Molecular Imaging. 2007 ; Vol. 34, No. 7. pp. 1039-1049.
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abstract = "Purpose: A procedure for the measurement of spatial dose rate distribution of beta particles emitted by 186Re-liposomes in tumoral tissue, using HS GafChromic films, is presented. Methods: HNSCC xenografts were intratumorally injected with 3.7 or 11.1 MBq of 186Re-liposomes, and planar gamma camera images were acquired to determine the liposome retention in the tumor. After imaging, rats were sacrificed and tumors were excised and processed in slices; HS film sections were placed between slices and the tumor lobe was reassembled. Tumors and films were kept in the dark at 4°C for 18 h. After irradiation, films were removed and response was read using a transmission scanner. Films were analyzed to determine two-dimensional spatial dose rate distributions and cumulative dose volume histograms. Dose rate distributions were quantified using a 60Co calibration curve, the 186Re physical half-life, and a perturbation factor that takes into account the effect of the film protective layer. Results: Dose rate distributions are highly heterogeneous with maximal dose rates about 0.4 Gy h-1 in tumors injected with 3.7 MBq and 1.3 Gy h-1 in tumors injected with 11.1 MBq. Dose volume histograms showed dose distributed in more than 95{\%} and 80{\%} of the tumor when injected with the lower and the higher activity, respectively. Conclusion: The described procedures and techniques have shown the potential and utility of HS GafChromic film for determination of dose rate distributions in solid tumors injected intratumorally with 186Re-liposomes. The film's structure and the liposomes' biodistribution must be taken into account to obtain quantitative dose measurements.",
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AU - Medina, Luis A.

AU - Goins, Beth

AU - Rodríguez-Villafuerte, Mercedes

AU - Bao, Ande

AU - Martínez-Davalos, Arnulfo

AU - Awasthi, Vibhudutta

AU - Galván, Olga O.

AU - Santoyo, Cristina

AU - Phillips, William T

AU - Brandan, María Ester

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N2 - Purpose: A procedure for the measurement of spatial dose rate distribution of beta particles emitted by 186Re-liposomes in tumoral tissue, using HS GafChromic films, is presented. Methods: HNSCC xenografts were intratumorally injected with 3.7 or 11.1 MBq of 186Re-liposomes, and planar gamma camera images were acquired to determine the liposome retention in the tumor. After imaging, rats were sacrificed and tumors were excised and processed in slices; HS film sections were placed between slices and the tumor lobe was reassembled. Tumors and films were kept in the dark at 4°C for 18 h. After irradiation, films were removed and response was read using a transmission scanner. Films were analyzed to determine two-dimensional spatial dose rate distributions and cumulative dose volume histograms. Dose rate distributions were quantified using a 60Co calibration curve, the 186Re physical half-life, and a perturbation factor that takes into account the effect of the film protective layer. Results: Dose rate distributions are highly heterogeneous with maximal dose rates about 0.4 Gy h-1 in tumors injected with 3.7 MBq and 1.3 Gy h-1 in tumors injected with 11.1 MBq. Dose volume histograms showed dose distributed in more than 95% and 80% of the tumor when injected with the lower and the higher activity, respectively. Conclusion: The described procedures and techniques have shown the potential and utility of HS GafChromic film for determination of dose rate distributions in solid tumors injected intratumorally with 186Re-liposomes. The film's structure and the liposomes' biodistribution must be taken into account to obtain quantitative dose measurements.

AB - Purpose: A procedure for the measurement of spatial dose rate distribution of beta particles emitted by 186Re-liposomes in tumoral tissue, using HS GafChromic films, is presented. Methods: HNSCC xenografts were intratumorally injected with 3.7 or 11.1 MBq of 186Re-liposomes, and planar gamma camera images were acquired to determine the liposome retention in the tumor. After imaging, rats were sacrificed and tumors were excised and processed in slices; HS film sections were placed between slices and the tumor lobe was reassembled. Tumors and films were kept in the dark at 4°C for 18 h. After irradiation, films were removed and response was read using a transmission scanner. Films were analyzed to determine two-dimensional spatial dose rate distributions and cumulative dose volume histograms. Dose rate distributions were quantified using a 60Co calibration curve, the 186Re physical half-life, and a perturbation factor that takes into account the effect of the film protective layer. Results: Dose rate distributions are highly heterogeneous with maximal dose rates about 0.4 Gy h-1 in tumors injected with 3.7 MBq and 1.3 Gy h-1 in tumors injected with 11.1 MBq. Dose volume histograms showed dose distributed in more than 95% and 80% of the tumor when injected with the lower and the higher activity, respectively. Conclusion: The described procedures and techniques have shown the potential and utility of HS GafChromic film for determination of dose rate distributions in solid tumors injected intratumorally with 186Re-liposomes. The film's structure and the liposomes' biodistribution must be taken into account to obtain quantitative dose measurements.

KW - Re

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KW - Intratumoral dosimetry

KW - Liposomes

KW - MC simulation

KW - Radionuclide therapy

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