Spasticity may obscure motor learning ability after stroke

Sandeep K. Subramanian, Anatol G. Feldman, Mindy F. Levin

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Previous motor learning studies based on adapting movements of the hemiparetic arm in stroke subjects have not accounted for spasticity occurring in specific joint ranges (spasticity zones), resulting in equivocal conclusions about learning capacity. We compared the ability of participants with stroke to rapidly adapt elbow extension movements to changing external load conditions outside and inside spasticity zones. Participants with stroke (n = 12, aged 57.8 ± 9.6 yr) and healthy age-matched controls (n = 8, 63.5 ± 9.1 yr) made rapid 40°–50° horizontal elbow extension movements from an initial (3°) to a final (6°) target. Sixteen blocks (6–10 trials/block) consisting of alternating loaded (30% maximal voluntary contraction) and non-loaded trials were made in one (controls) or two sessions (stroke; 1 wk apart). For the stroke group, the tonic stretch reflex threshold angle at which elbow flexors began to be activated during passive elbow extension was used to identify the beginning of the spasticity zone. The task was repeated in joint ranges that did or did not include the spasticity zone. Error correction strategies were identified by the angular positions before correction and compared between groups and sessions. Changes in load condition from no load to load and vice versa resulted in undershoot and overshoot errors, respectively. Stroke subjects corrected errors in 1–4 trials compared with 1–2 trials in controls. When movements did not include the spasticity zone, there was an immediate decrease in the number of trials needed to restore accuracy, suggesting that the capacity to learn may be preserved after stroke but masked by the presence of spasticity. NEW & NOTEWORTHY When arm movements were made outside, instead of inside, the range affected by spasticity, there was an immediate decrease in the number of trials needed to restore accuracy in response to a change in the external load. This suggests that motor learning processes may be preserved in patients with stroke but masked by the presence of spasticity in specific joint ranges. This has important implications for designing rehabilitation interventions predicated on motor learning principles.

Original languageEnglish (US)
Pages (from-to)5-20
Number of pages16
JournalJournal of neurophysiology
Volume119
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Goal-directed behavior
  • Motor control
  • Motor learning
  • Spasticity
  • Stroke rehabilitation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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