Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women

Shenghui Wu, Xiao Ou Shu, Wong Ho Chow, Yong Bing Xiang, Xianglan Zhang, Hong Lan Li, Qiuyin Cai, Bu Tian Ji, Hui Cai, Nathaniel Rothman, Yu Tang Gao, Wei Zheng, Gong Yang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Soy and some of its constituents, such as isoflavones, have been shown to affect the inflammatory process in animal studies. The association between soy food intake and inflammatory markers has not been evaluated adequately in humans. Objective: Our aim was to evaluate whether higher intake of soy foods was inversely associated with inflammatory markers in 1,005 middle-aged Chinese women. Design: In this cross-sectional study, dietary intake of soy foods was assessed by a validated food frequency questionnaire and by a 24-hour recall when biospecimens were procured. A general linear model was used to estimate the geometric means of selected inflammatory markers, including interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNFα), soluble IL-6 receptor, soluble GP130, soluble TNF receptors 1 and 2, and C-reactive protein, across categories of soy food intake after adjusting for age, lifestyle and dietary factors, and history of infectious or inflammation-related diseases. Results: We found that multivariable-adjusted geometric mean concentrations of IL-6 and TNFα were inversely associated with quintiles of soy food intake, with a difference between the highest and lowest quintiles of 25.5% for IL-6 (P for trend=0.008) and 14% for TNFα (P for trend=0.04). Similar inverse associations were found for TNFα (P for trend =0.003), soluble TNF receptor 1 (P for trend=0.01), soluble TNF receptor 2 (P for trend=0.02), IL-1β (P for trend=0.05), and IL-6 (P for trend=0.04) when soy food consumption was assessed by the frequency of consumption in the preceding 24 hours. No significant associations were found for other markers studied. Conclusions: This study suggests that soy food consumption is related to lower circulating levels of IL-6, TNFα, and soluble TNF receptors 1 and 2 in Chinese women.

Original languageEnglish (US)
JournalJournal of the Academy of Nutrition and Dietetics
Volume112
Issue number7
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Soy Foods
tumor necrosis factors
food intake
Eating
interleukin-6
Interleukin-6
Receptors, Tumor Necrosis Factor, Type II
Tumor Necrosis Factor-alpha
receptors
Interleukin-1
interleukin-1
Cytokine Receptor gp130
food consumption
Interleukin-6 Receptors
Isoflavones
middle-aged adults
Tumor Necrosis Factor Receptors
diet history
C-Reactive Protein
Life Style

Keywords

  • Inflammation
  • Interleukin-1β
  • Interleukin-6
  • Soy
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women. / Wu, Shenghui; Shu, Xiao Ou; Chow, Wong Ho; Xiang, Yong Bing; Zhang, Xianglan; Li, Hong Lan; Cai, Qiuyin; Ji, Bu Tian; Cai, Hui; Rothman, Nathaniel; Gao, Yu Tang; Zheng, Wei; Yang, Gong.

In: Journal of the Academy of Nutrition and Dietetics, Vol. 112, No. 7, 01.07.2012.

Research output: Contribution to journalArticle

Wu, S, Shu, XO, Chow, WH, Xiang, YB, Zhang, X, Li, HL, Cai, Q, Ji, BT, Cai, H, Rothman, N, Gao, YT, Zheng, W & Yang, G 2012, 'Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women', Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 7. https://doi.org/10.1016/j.jand.2012.04.001
Wu, Shenghui ; Shu, Xiao Ou ; Chow, Wong Ho ; Xiang, Yong Bing ; Zhang, Xianglan ; Li, Hong Lan ; Cai, Qiuyin ; Ji, Bu Tian ; Cai, Hui ; Rothman, Nathaniel ; Gao, Yu Tang ; Zheng, Wei ; Yang, Gong. / Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women. In: Journal of the Academy of Nutrition and Dietetics. 2012 ; Vol. 112, No. 7.
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AU - Zhang, Xianglan

AU - Li, Hong Lan

AU - Cai, Qiuyin

AU - Ji, Bu Tian

AU - Cai, Hui

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AU - Zheng, Wei

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