A double-blind, placebo-controlled and dose ranging study on 331 osteopenic postmenopausal women treated with either placebo or idoxifene for 12 weeks was conducted. In these women, endometrial assessment was carried out by transvaginal sonography and endometrial biopsy on selected patients at baseline and on all women at the end of treatment. Women with endometrial thickness greater than 10 mm were excluded from the study. Aspiration endometrial biopsy was performed on women with an endometrial thickness between 6 and 10 mm at baseline and on all women after treatment. Of the 298 biopsies performed in the subjects at the end of the treatment, 99% of the women were reported to have either a benign or atrophic endometrium or insufficient tissue.
- Selective estrogen receptor modulator
- Transvaginal sonography
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging