Sonographic assessment of the endometrium in osteopenic postmenopausal women treated with idoxifene

Arthur C. Fleischer, James E. Wheeler, I. Tien Yeh, Barbara Kravitz, Colleen Jensen, Brian MacDonald

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

A double-blind, placebo-controlled and dose ranging study on 331 osteopenic postmenopausal women treated with either placebo or idoxifene for 12 weeks was conducted. In these women, endometrial assessment was carried out by transvaginal sonography and endometrial biopsy on selected patients at baseline and on all women at the end of treatment. Women with endometrial thickness greater than 10 mm were excluded from the study. Aspiration endometrial biopsy was performed on women with an endometrial thickness between 6 and 10 mm at baseline and on all women after treatment. Of the 298 biopsies performed in the subjects at the end of the treatment, 99% of the women were reported to have either a benign or atrophic endometrium or insufficient tissue.

Original languageEnglish (US)
Pages (from-to)503-512
Number of pages10
JournalJournal of Ultrasound in Medicine
Volume18
Issue number7
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Endometrium
  • Selective estrogen receptor modulator
  • Transvaginal sonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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