TY - JOUR
T1 - Some thoughts on the relations between animal and human drug-taking
AU - Woods, James H.
N1 - Funding Information:
This paper was supported by USPHS Grant DA 00154 and DA 00254. edited by G. Winger and typed by S. Baibak; both chores were done with
PY - 1983
Y1 - 1983
N2 - 1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion for drugs such as morphine and ethanol that served as reinforcers in both human and non-human experimental subjects. More recent information Indicated that, while the correlation between human and non-human drug self-administistration may be high, there are apparently, occasional exceptions. In the narcotic analysis and antidepressant classes of pharmacological compounds, there are drugs that maintain high response rates in animals, but have not yet been shown to result in significant abuse problems in man. Various methodological issues, related to the general proposition and the exceptions to it are discussed.
AB - 1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion for drugs such as morphine and ethanol that served as reinforcers in both human and non-human experimental subjects. More recent information Indicated that, while the correlation between human and non-human drug self-administistration may be high, there are apparently, occasional exceptions. In the narcotic analysis and antidepressant classes of pharmacological compounds, there are drugs that maintain high response rates in animals, but have not yet been shown to result in significant abuse problems in man. Various methodological issues, related to the general proposition and the exceptions to it are discussed.
KW - animals
KW - drug self-administration
KW - human reinforcing effects
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U2 - 10.1016/0278-5846(83)90028-3
DO - 10.1016/0278-5846(83)90028-3
M3 - Article
C2 - 6686694
AN - SCOPUS:0021022433
VL - 7
SP - 577
EP - 584
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 4-6
ER -