Some studies on the distribution and effects of cyclophosphamide (NSC 26271) in normal and neoplastic tissues

P. J. Houghton, K. D. Tew, D. M. Taylor

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The gross uptake and intracellular distribution of 32P cyclophosphamide has been studied in normal and neoplastic rat and mouse tissues. Prolonged alkylation of DNA and RNA occurs over periods of 24 hours in the mouse and 48 hours in the rat, and it is suggested that this may involve slow release of active metabolites from a drug macromolecule complex. The survival of cells in pulmonary and sc tumors after cyclophosphamide treatment has been studied in situ using a biochemical assay, and the influence of environmental factors at the tumor site has been assessed. The pattern of drug distribution has been studied in large sc tumors, and in one tumor line the drug concentration achieved has been related to estimated cell survival.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalCANCER TREAT.REP.
Volume60
Issue number4
StatePublished - Dec 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Some studies on the distribution and effects of cyclophosphamide (NSC 26271) in normal and neoplastic tissues'. Together they form a unique fingerprint.

Cite this