Somatosensory scaffolding structures

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Dynamic changes in somatosensory perception occur as a result of multiple signaling events. In many instances, over-activation of sensory receptors results in the desensitization and subsequent increased threshold for activation of receptors. In other cases, receptor sensitization can occur following tissue injury and/or inflammation. In both cases, signaling mechanisms that control alterations in receptor activities can significantly affect organism response to sensory stimuli, including thermal, mechanical, and chemical. Due to the homeostatic nature of somatosensory recognition, dynamic changes in receptor response can negatively affect an individual's way of life, as well as alert individuals to tissue damage. Here, we will focus on scaffolding structures that regulate somatosensory neuronal excitability.

Original languageEnglish (US)
Article number2
JournalFrontiers in Molecular Neuroscience
Issue numberJANUARY 2012
DOIs
StatePublished - 2012

Keywords

  • AKAP
  • Afferent
  • Homer
  • Jeske
  • Lipid raft
  • Pain
  • Scaffold

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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