Somatic immunoglobulin hypermutation

Marilyn Diaz, Paolo Casali

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalCurrent Opinion in Immunology
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 1 2002

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this