Somatic immunoglobulin hypermutation

Marilyn Diaz; Paolo Casali

doi:10.1016/S0952-7915(02)00327-8

Somatic immunoglobulin hypermutation

Marilyn Diaz, Paolo Casali

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

Original language	English (US)
Pages (from-to)	235-240
Number of pages	6
Journal	Current Opinion in Immunology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(02)00327-8
State	Published - Apr 1 2002
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(02)00327-8

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title = "Somatic immunoglobulin hypermutation",

abstract = "Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.",

author = "Marilyn Diaz and Paolo Casali",

note = "Funding Information: We are grateful to Norman Klinman and Hong Zan for helpful discussions and comments on the manuscript. This work was supported by National Institutes of Health (NIH) grants AR 40908, AI 45011, AG 13910 and AI 07621 to PC; MD is currently supported by NIH Training Grant T32 A1-07244. ",

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AU - Diaz, Marilyn

AU - Casali, Paolo

N1 - Funding Information: We are grateful to Norman Klinman and Hong Zan for helpful discussions and comments on the manuscript. This work was supported by National Institutes of Health (NIH) grants AR 40908, AI 45011, AG 13910 and AI 07621 to PC; MD is currently supported by NIH Training Grant T32 A1-07244.

PY - 2002/4/1

Y1 - 2002/4/1

N2 - Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

AB - Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

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Somatic immunoglobulin hypermutation

Abstract

ASJC Scopus subject areas

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