Abstract
Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-240 |
| Number of pages | 6 |
| Journal | Current Opinion in Immunology |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2002 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Cite this
Diaz, M., & Casali, P. (2002). Somatic immunoglobulin hypermutation. Current Opinion in Immunology, 14(2), 235-240. https://doi.org/10.1016/S0952-7915(02)00327-8