Somatic immunoglobulin hypermutation

Marilyn Diaz; Paolo Casali

doi:10.1016/S0952-7915(02)00327-8

Somatic immunoglobulin hypermutation

Marilyn Diaz, Paolo Casali

Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Review article

69 Scopus citations

Abstract

Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

Original language	English (US)
Pages (from-to)	235-240
Number of pages	6
Journal	Current Opinion in Immunology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(02)00327-8
Publication status	Published - Apr 1 2002

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ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

Diaz, M., & Casali, P. (2002). Somatic immunoglobulin hypermutation. Current Opinion in Immunology, 14(2), 235-240. https://doi.org/10.1016/S0952-7915(02)00327-8

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10.1016/S0952-7915(02)00327-8