Somatic cell genetic studies of the cystic fibrosis mucociliary inhibitor

B. J. Mayo, R. J. Klebe, D. R. Barnett, B. J. Lankford, B. H. Bowman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A series of cystic fibrosis homozygous fibroblast X mouse cell hybrids were constructed in order to determine the chromosome which carries the gene controlling the cystic fibrosis mucociliary inhibitor (CFMI) phenotype. Several hybrids and their subclones retained the CFMI phenotype for long periods in cell culture. Correlation of the CFMI phenotype with the presence of specific human chromosomes indicated that possible linkage existed between CFMI and human chromosomes 2, 4, 6, 10, and 18. The strongest chance of linkage existed for chromosome 4.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalUnknown Journal
Volume18
Issue number5
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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